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多糖-蛋白质复合物修饰的硒纳米系统作为一种高效的骨形成治疗剂。

Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic.

作者信息

Yu Siming, Luk Kar-Him, Cheung Siu-To, Kwok Kevin Wing-Hin, Wong Ka-Hing, Chen Tianfeng

机构信息

Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.

出版信息

J Mater Chem B. 2018 Aug 28;6(32):5215-5219. doi: 10.1039/c8tb01084f. Epub 2018 Jul 25.

DOI:10.1039/c8tb01084f
PMID:32254758
Abstract

Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.

摘要

多糖-蛋白质复合物包被的硒纳米颗粒（PTR-SeNPs）系统已被合理设计，并被确定为一种有效的抗骨质疏松骨形成治疗剂。该纳米系统在成骨细胞中具有高细胞摄取率，并主要通过BMP-2/Smad介导的信号通路在体外和体内显著增强骨形成。

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