School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology, Tianjin 300384, P. R. China.
J Mater Chem B. 2019 Feb 21;7(7):1160-1166. doi: 10.1039/c8tb02570c. Epub 2019 Jan 30.
Near-infrared (NIR) light-induced photothermal agent-based stimuli-responsive materials have attracted great interest from researchers. However, the highly smart release with precise control by NIR light is not yet well established because of the lack or inadequacy of intelligent release systems, such as premature release of drug and/or photothermal agent. Herein, we put forward a novel and convenient strategy to synthesize cyanine dye-functionalized polymeric materials, where cyanine dye was schemed to attach to polymeric materials by copolymerization, endowing the polymeric materials with NIR light-responsive photothermal property and fluorescent nature for real-time imaging of endocytosis and intracellular trafficking of nanovehicles. Meanwhile, the chemotherapy drug DOX was introduced into the cyanine-containing polymeric materials via formation of dynamic covalent hydrazone bond to circumvent the blood circulation barrier. The nanovehicles displayed fine pH/NIR light-controlled drug release and excellent tumor intracellular drug transposition, which were ulteriorly combined with photo-triggered hyperthermia for enhanced antitumor effect. Therefore, this multipronged design of theranostic nanovehicles with endogenous and exogenous stimuli-responsiveness provides a novel strategy to attain highly smart drug delivery for precise cancer therapy.
近红外（NIR）光诱导光热剂响应性材料引起了研究人员的极大兴趣。然而，由于智能释放系统的缺乏或不足，例如药物和/或光热剂的过早释放，通过 NIR 光实现的高度智能释放和精确控制尚未得到很好的建立。在此，我们提出了一种新颖且方便的策略来合成菁染料功能化的聚合物材料，其中通过共聚将菁染料设计为连接到聚合物材料上，赋予聚合物材料 NIR 光响应的光热特性和荧光性质，用于纳米载体的内吞作用和细胞内运输的实时成像。同时，通过形成动态共价腙键将化疗药物 DOX 引入含菁聚合物材料中，以规避血液循环障碍。纳米载体显示出精细的 pH/NIR 光控药物释放和优异的肿瘤细胞内药物转位，进一步与光触发的热疗相结合，以增强抗肿瘤效果。因此，这种具有内源性和外源性刺激响应性的治疗诊断纳米载体的多管齐下的设计为实现精确癌症治疗的高度智能药物输送提供了一种新策略。
