Fang Danruo, Liu Zeyu, Jin Hansong, Huang Xiulin, Shi Yongxin, Ben Suqin
Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Respiratory and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Front Bioeng Biotechnol. 2022 Jun 22;10:939158. doi: 10.3389/fbioe.2022.939158. eCollection 2022.
Based on the safety of prussian blue (PB) in biomedical application, we prepared manganese-based prussian blue (MnPB) nanocatalysts to achieve enhanced photothermal therapy and chemodynamic therapy. And we conducted a series of experiments to explore the therapeutic effects of MnPB nanoparticles (NPs) on non-small cell lung cancer (NSCLC) and . For experiments, the MnPB NPs suppressed growth of A549 cells by reactive oxygen species upregulation and near-infrared irradiation. Moreover, the MnPB NPs could inhibit lung cancer metastasis through downregulating the matrix metalloproteinase (MMP)-2 and MMP-9 expression in A549 cells. And for experiments, the MnPB NPs inhibited the growth of xenografted tumor effectively and were biologically safe. Meanwhile, Mn as a T1-weighted agent could realize magnetic resonance imaging-guided diagnosis and treatment. To sum up, the results in this study clearly demonstrated that the MnPB NPs had remarkable effects for inhibiting the growth and metastasis of NSCLC and might serve as a promising multifunctional nanoplatform for NSCLC treatment.
基于普鲁士蓝（PB）在生物医学应用中的安全性，我们制备了锰基普鲁士蓝（MnPB）纳米催化剂，以实现增强的光热疗法和化学动力学疗法。并且我们进行了一系列实验，以探究MnPB纳米颗粒（NPs）对非小细胞肺癌（NSCLC）的治疗效果。在实验中，MnPB NPs通过上调活性氧和近红外照射抑制了A549细胞的生长。此外，MnPB NPs可通过下调A549细胞中基质金属蛋白酶（MMP）-2和MMP-9的表达来抑制肺癌转移。在实验中，MnPB NPs有效抑制了异种移植肿瘤的生长且具有生物安全性。同时，锰作为一种T1加权剂可实现磁共振成像引导的诊断和治疗。综上所述，本研究结果清楚地表明，MnPB NPs对抑制NSCLC的生长和转移具有显著效果，可能成为一种有前景的用于NSCLC治疗的多功能纳米平台。
