Sheng Jie, Wang Xinyu, Yan Junjie, Pan Donghui, Yang Runlin, Wang Lizhen, Xu Yuping, Yang Min
The First School of Clinical Medicine, Nanjing Medical University, Nanjing, 210029, China.
J Mater Chem B. 2018 Dec 28;6(48):8163-8169. doi: 10.1039/c8tb02817f. Epub 2018 Nov 23.
Radioiodine is widely used in nuclear medicine, mainly serving as a tracer and therapeutic agent, and benefits from its various radioactive isotopes of iodine including I-123, I-124, I-125, I-131 and so on. Melanin is a natural material widely dispersed in the human skin, hair and eyes. The excellent biocompatibility and multifunctional abilities of melanin make it a perfect carrier for biomedical applications. Here, we fabricated theranostic radioiodine-labelled melanin nanoparticles (MNPs) through a novel Ag-I two-step method. The Ag-I labelling method for MNP radioiodine-labelling has advantages including a faster labelling time, higher labelling yield, and higher stability than the chloramine-T oxidation method reported previously. The obtained MNP-Ag-I can be used for both single-photon emission computed tomography and Cherenkov radiation imaging. The β-rays of I also make it a good candidate as a cancer cell killer. The theranostic properties of this nanoparticle were also proved in a xenograft tumor model in vivo. In summary, this study provides a new concept for radioiodine labelling nanoparticles, which can be further investigated in various imaging and radiotherapy applications with different radioactive isotopes of iodine.
放射性碘在核医学中广泛应用，主要用作示踪剂和治疗剂，受益于其多种碘的放射性同位素，包括I-123、I-124、I-125、I-131等。黑色素是一种广泛分布于人体皮肤、头发和眼睛中的天然物质。黑色素优异的生物相容性和多功能特性使其成为生物医学应用的理想载体。在此，我们通过一种新颖的银-碘两步法制备了用于诊疗的放射性碘标记黑色素纳米颗粒（MNPs）。用于MNPs放射性碘标记的银-碘标记方法具有诸多优点，包括标记时间更快、标记产率更高以及比先前报道的氯胺-T氧化法具有更高的稳定性。所获得的MNP-Ag-I可用于单光子发射计算机断层扫描和切伦科夫辐射成像。I的β射线也使其成为癌细胞杀伤的良好候选者。这种纳米颗粒的诊疗特性也在体内异种移植肿瘤模型中得到了证实。总之，本研究为放射性碘标记纳米颗粒提供了一个新概念，可在使用不同碘放射性同位素的各种成像和放射治疗应用中进一步研究。
