Ha Shin-Woo, Cho Hee-Sang, Yoon Young Il, Jang Moon-Sun, Hong Kwan Soo, Hui Emmanuel, Lee Jung Hee, Yoon Tae-Jong
Medical Device R&D Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, 13605, South Korea.
Nanopharmacy Lab., College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
J Nanobiotechnology. 2017 Oct 10;15(1):73. doi: 10.1186/s12951-017-0304-3.
Multimodal nanomaterials are useful for providing enhanced diagnostic information simultaneously for a variety of in vivo imaging methods. According to our research findings, these multimodal nanomaterials offer promising applications for cancer therapy.
Melanin nanoparticles can be used as a platform imaging material and they can be simply produced by complexation with various imaging active ions. They are capable of specifically targeting epidermal growth factor receptor (EGFR)-expressing cancer cells by being anchored with a specific antibody. Ion-doped melanin nanoparticles were found to have high bioavailability with long-term stability in solution, without any cytotoxicity in both in vitro and in vivo systems.
By combining different imaging modalities with melanin particles, we can use the complexes to obtain faster diagnoses by computed tomography deep-body imaging and greater detailed pathological diagnostic information by magnetic resonance imaging. The ion-doped melanin nanoparticles also have applications for radio-diagnostic treatment and radio imaging-guided surgery, warranting further proof of concept experimental.
多模态纳米材料有助于同时为多种体内成像方法提供增强的诊断信息。根据我们的研究结果，这些多模态纳米材料在癌症治疗方面具有广阔的应用前景。
黑色素纳米颗粒可作为一种平台成像材料，通过与各种成像活性离子络合可简单制备。通过与特异性抗体结合，它们能够特异性靶向表达表皮生长因子受体（EGFR）的癌细胞。发现离子掺杂的黑色素纳米颗粒具有高生物利用度，在溶液中具有长期稳定性，在体外和体内系统中均无任何细胞毒性。
通过将不同的成像方式与黑色素颗粒相结合，我们可以利用这些复合物通过计算机断层扫描深部体部成像获得更快的诊断，并通过磁共振成像获得更详细的病理诊断信息。离子掺杂的黑色素纳米颗粒在放射诊断治疗和放射成像引导手术中也有应用，值得进一步进行概念验证实验。
