CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
J Mater Chem B. 2019 Apr 28;7(16):2588-2607. doi: 10.1039/c8tb03240h. Epub 2019 Mar 28.
Stimuli-responsive systems, which can be used for temporally and spatially controllable therapeutic platforms, have been widely investigated in cancer therapy. Among a wide range of stimuli-responsive nanomaterials, transition metal dichalcogenides (TMDCs) have recently attracted great attention due to their large surface-to-volume ratio, atomic thickness, and other unique physicochemical properties. Thus, TMDCs are able to be responsive to various endogenous (e.g. acidic pH and overexpressed enzymes) or exogenous stimuli (e.g. light and magnetic). The majority of TMDC-based therapeutic platforms are triggered by near-infrared (NIR) light. However, due to the limited penetration of NIR light, novel strategies that are able to ablate deep-seated tumor tissues have emerged in recent years and have been applied to design multi-stimuli-responsive nano-systems. A comprehensive overview of the development of stimuli-responsive TMDC-based nanoplatforms for "smart" cancer therapy is presented to demonstrate a more intelligent and better controllable therapeutic strategy. Furthermore, the versatile properties of TMDCs and the typical responsive principles of certain stimuli-responsive platforms are discussed for a better understanding of selected examples in this review.
刺激响应系统可用于时间和空间可控的治疗平台，已在癌症治疗中得到广泛研究。在广泛的刺激响应纳米材料中，过渡金属二硫属化物（TMDCs）由于其大的表面积与体积比、原子厚度和其他独特的物理化学性质而受到广泛关注。因此，TMDCs 能够响应各种内源性（例如酸性 pH 值和过表达的酶）或外源性刺激（例如光和磁）。大多数基于 TMDC 的治疗平台都是由近红外（NIR）光触发的。然而，由于 NIR 光的穿透深度有限，近年来出现了能够消融深层肿瘤组织的新型策略，并已应用于设计多刺激响应纳米系统。本文全面概述了用于“智能”癌症治疗的刺激响应 TMDC 基纳米平台的发展，以展示更智能和更好可控的治疗策略。此外，还讨论了 TMDCs 的多功能特性和某些刺激响应平台的典型响应原理，以更好地理解本综述中选择的示例。
