State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.
Pharmacol Res. 2022 Apr;178:106184. doi: 10.1016/j.phrs.2022.106184. Epub 2022 Mar 14.
With the rapid development of nanotechnology, strategies related to nanomedicine have been used to overcome the shortcomings of traditional chemotherapy drugs, thereby demonstrating significant potential for innovative drug delivery. Nanomaterials play an increasingly important role in cancer immunotherapy. Stimuli-responsive nanomaterials enable the precise control of drug release through exposure to specific stimuli and exhibit excellent specificity in response to various stimuli. Immunomodulators carried by nanomaterials can also effectively regulate the immune system and significantly improve their therapeutic effect on cancer. In recent years, stimuli-responsive nanomaterials have evolved rapidly from single stimuli-responsive systems to multi-stimuli-responsive systems. This review focuses on recent advances in the design and applications of stimuli-responsive nanomaterials, including exogenous and endogenous responsive nanoscale drug delivery systems, which show extraordinary potential in intelligent drug delivery for multimodal cancer diagnosis and treatment. Ultimately, the opportunities and challenges in the development of intelligent responsive nanomaterials are briefly discussed according to recent advances in multi-stimuli-responsive systems.
随着纳米技术的快速发展，与纳米医学相关的策略被用于克服传统化疗药物的缺点，从而为创新药物输送展示了巨大的潜力。纳米材料在癌症免疫治疗中发挥着越来越重要的作用。刺激响应型纳米材料能够通过暴露于特定刺激来精确控制药物释放，并对各种刺激表现出优异的特异性。纳米材料携带的免疫调节剂还可以有效调节免疫系统，显著提高其对癌症的治疗效果。近年来，刺激响应型纳米材料已从单一刺激响应系统迅速发展为多刺激响应系统。本综述重点介绍了刺激响应型纳米材料的设计和应用的最新进展，包括外源性和内源性响应纳米级药物输送系统，它们在多模式癌症诊断和治疗的智能药物输送中显示出非凡的潜力。最后，根据多刺激响应系统的最新进展，简要讨论了智能响应纳米材料的发展机遇和挑战。
