Kaur Navneet, Chopra Shweta, Singh Gagandeep, Raj Pushap, Bhasin Aman, Sahoo Suban K, Kuwar Anil, Singh Narinder
Department of Chemistry, Panjab University (PU), Chandigarh-160014, India.
J Mater Chem B. 2018 Aug 14;6(30):4872-4902. doi: 10.1039/c8tb00732b. Epub 2018 Jul 20.
There is burgeoning interest among supramolecular chemists to develop novel molecular systems to detect biogenic amines and bio-thiols in aqueous and non-aqueous media due to their potential role in biological processes. Biogenic amines are biologically important targets because of their involvement in the energy metabolism of human biological systems and their requirement is met through food and nutrition. However, the increasing instances of serious health problems due to food toxicity have raised the quality of food nowadays. Biogenic amines have been frequently considered as the markers or primary quality parameters of foods like antioxidant properties, freshness and spoilage. For instance, these amines such as spermine, spermidine, cadavarine, etc. may originate during microbial decarboxylation of amino acids of fermented foods/beverages. These amines may also react with nitrite available in certain meat products and concomitantly produce carcinogenic nitrosamine compounds. On the other hand, it is also well established that biothiols, particularly, thiol amino acids, provide the basic characteristics to food including flavor, color and texture that determine its acceptability. For instance, the reduction of thiol groups produces hydrogen sulfide which reduces flavour as in rotten eggs and spoiled fish, and the presence of hydrogen sulfide in fish is indicative of spoilage. Thus, biogenic amines and bio-thiols have attracted the profound interest of researchers as analytical tools for their quantification. Much scientific and technological information is issued every year, where the establishment of precise interactions of biogenic amines and bio-thiols with other molecules is sought in aqueous and non-aqueous media. This review summarizes the optical chemosensors developed for the selective detection of biogenic amines and bio-thiols.
超分子化学家对开发新型分子系统以检测水性和非水性介质中的生物胺和生物硫醇兴趣渐浓，因为它们在生物过程中具有潜在作用。生物胺是生物学上重要的目标，因为它们参与人类生物系统的能量代谢，并且通过食物和营养来满足其需求。然而，由于食物毒性导致严重健康问题的情况日益增多，如今人们对食物质量的要求也提高了。生物胺经常被视为食品的标志物或主要质量参数，如抗氧化性能、新鲜度和变质情况。例如，精胺、亚精胺、尸胺等这些胺类可能在发酵食品/饮料中氨基酸的微生物脱羧过程中产生。这些胺类也可能与某些肉类产品中存在的亚硝酸盐反应，并随之产生致癌的亚硝胺化合物。另一方面，生物硫醇，特别是硫醇氨基酸，赋予食物基本特性，包括决定其可接受性的风味、颜色和质地，这一点也已得到充分证实。例如，硫醇基团的还原会产生硫化氢，就像在臭鸡蛋和变质鱼中那样，硫化氢会降低风味，鱼中硫化氢的存在表明其已变质。因此，生物胺和生物硫醇作为定量分析工具引起了研究人员的浓厚兴趣。每年都会发布大量科学技术信息，其中寻求在水性和非水性介质中建立生物胺和生物硫醇与其他分子的精确相互作用。本综述总结了为选择性检测生物胺和生物硫醇而开发的光学化学传感器。
