State Key Lab for Strength and Vibration of Mechanical Structures, Department of Engineering Mechanics, Xi'an Jiaotong University, Xi'an 710049, China.
J Mater Chem B. 2019 Feb 28;7(8):1311-1321. doi: 10.1039/c8tb03301c. Epub 2019 Feb 4.
Magnetic-field driven soft materials have found extensive applications in fields such as soft robotics, shape morphing and biomedicine. Compared to magnetoactive elastomers (MAEs), magnetic hydrogels have shown significant advantages for in vivo applications, because of their better biocompatibility, as well as their soft and wet nature. However, the poor mechanical properties and ion sensitivity of conventional magnetic hydrogels will severely limit their applications especially under physiological conditions. Double network hydrogels are tough and stable, but do not respond to environmental stimuli. Here magnetic double network (M-DN) hydrogels have been developed with outstanding mechanical performances and ion-resistant stability. M-DN hydrogels show a high modulus of ∼0.4 MPa and a high toughness of ∼1500 J m. The volume, magnetic and mechanical properties of M-DN hydrogels show negligible deterioration in ionic solutions. M-DN hydrogels exhibit magnetic responsiveness and have been used for tissue hyperthermia and drug release by magnetic induction heating. The induction heating behavior of M-DN hydrogels can be tuned to meet the clinical requirements, by changing the magnetic field strength or the composition of magnetic hydrogels. M-DN hydrogels may be inspiring to the development of responsive DN hydrogels and expand their more potential applications in load-bearing biomedical engineering.
磁场驱动的软材料在软机器人、形状变形和生物医学等领域得到了广泛的应用。与磁致伸缩弹性体（MAE）相比，由于具有更好的生物相容性以及柔软和湿润的特性，磁性水凝胶在体内应用中显示出了显著的优势。然而，传统磁性水凝胶的机械性能差和对离子敏感会严重限制其应用，尤其是在生理条件下。双网络水凝胶具有很强的韧性和稳定性，但对环境刺激没有反应。在这里，开发了具有优异机械性能和耐离子稳定性的磁性双网络（M-DN）水凝胶。M-DN 水凝胶表现出约 0.4 MPa 的高模量和约 1500 J m 的高韧性。M-DN 水凝胶在离子溶液中的体积、磁性和机械性能几乎没有恶化。M-DN 水凝胶具有磁响应性，可通过磁感应加热用于组织热疗和药物释放。通过改变磁场强度或磁性水凝胶的组成，可以调整 M-DN 水凝胶的感应加热行为，以满足临床要求。M-DN 水凝胶可能会激发响应性双网络水凝胶的发展，并扩大其在承重生物医学工程中的更多潜在应用。
