膳食钙通过调节肾脏脂质代谢、氧化应激和炎症来调节高脂饮食诱导肥胖大鼠的肾脏损伤风险。
Dietary calcium regulates the risk renal injury in high fat diet induced obese rats by regulating renal lipid metabolism, oxidative stress and inflammation.
机构信息
Reproductive Physiology and Endocrinology Laboratory, Department of Human Physiology, Tripura University (A Central University), Suryamaninagar, Agartala, India.
出版信息
Arch Physiol Biochem. 2022 Aug;128(4):1039-1049. doi: 10.1080/13813455.2020.1746812. Epub 2020 Apr 7.
CONTEXT
The antiobesity effect of dietary calcium by preventing fat accumulation and weight gain was well established from several epidemiological and animal studies.
OBJECTIVE
To evaluate the effect of dietary calcium against obesity-associated with renal injury in high fat diet induced obese rats. Materials and Methods: Obesity was induced by high fat diet (HFD) and then given either low or high calcium HFD (0.25% and 1.0%) for another 30 days.
RESULTS
The results showed that 1.0% high calcium group was effective in reducing renal lipogenesis activity, lipid accumulation, fatty acid synthase (FAS) activity, acetyl coenzyme A carboxylase (ACC) expression, oxidative stress, inflammation and increased the adenosine monophosphate kinase (AMPK) expression.
DISCUSSION AND CONCLUSION
Downregulation of renal lipid accumulation by high calcium diet through AMPK mediated lipogenesis activity, oxidative stress and the inflammatory response seemed to prevent the renal injury in high fat diet (HFD) induced obese rats.
背景
通过防止脂肪堆积和体重增加，饮食钙的抗肥胖作用已在多项流行病学和动物研究中得到充分证实。
目的
评估膳食钙对高脂肪饮食诱导肥胖大鼠肥胖相关肾损伤的作用。
材料和方法
通过高脂肪饮食（HFD）诱导肥胖，然后再给予低钙或高钙 HFD（0.25%和 1.0%）30 天。
结果
结果表明，1.0%高钙组可有效降低肾脏脂肪生成活性、脂质积累、脂肪酸合酶（FAS）活性、乙酰辅酶 A 羧化酶（ACC）表达、氧化应激、炎症，并增加单磷酸腺苷激酶（AMPK）表达。
讨论与结论
高钙饮食通过 AMPK 介导的脂肪生成活性、氧化应激和炎症反应下调肾脏脂质积累，似乎可预防高脂肪饮食（HFD）诱导肥胖大鼠的肾脏损伤。
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