Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
School of International Education, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Phytother Res. 2020 Oct;34(10):2438-2458. doi: 10.1002/ptr.6694. Epub 2020 Apr 7.
Malignant tumor endangers seriously the health of all mankind. Multidrug resistance (MDR) is one of the main causes of clinical tumor chemotherapy failure. Curcumin (CUR) has not only antitumor activity but also reversing tumor MDR effect. CUR reverses tumor MDR via regulating related signal pathways or corresponding expressed proteins or gene. When combined with chemotherapeutic agents, CUR can be a chemotherapeutic sensitive agent to enhance chemotherapy efficacy and weaken tumor MDR. On the other hand, to improve the MDR reversal effect of CUR, its derivatives have been extensively studied. Therefore, this article mainly focuses on reviewing the application of CUR and its derivatives in MDR and its mechanism of reversing MDR.
恶性肿瘤严重威胁着全人类的健康。多药耐药（MDR）是临床肿瘤化疗失败的主要原因之一。姜黄素（CUR）不仅具有抗肿瘤活性，而且具有逆转肿瘤 MDR 的作用。CUR 通过调节相关信号通路或相应表达的蛋白或基因来逆转肿瘤 MDR。CUR 与化疗药物联合使用时，可以作为化疗增敏剂，增强化疗疗效，减弱肿瘤 MDR。另一方面，为了提高 CUR 的 MDR 逆转效果，对其衍生物进行了广泛的研究。因此，本文主要综述 CUR 及其衍生物在 MDR 中的应用及其逆转 MDR 的机制。
