Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Department of Photodynamic, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran.
Phytother Res. 2020 Oct;34(10):2534-2556. doi: 10.1002/ptr.6703. Epub 2020 Apr 19.
Chemotherapy is one of the main methods for cancer treatment. However, despite many advances in the design of anticancer drugs, their efficiency is limited due to their high toxicity and resistance of cells to chemotherapeutic drugs. In order to improve the cancer therapy, it is essential to use the compounds that can overcome drug resistance and increase treatment efficiency. Researchers have studied the effects of natural compounds for the controlling various drug resistance mechanisms. Curcumin is a natural phenolic compound which shows potent anticancer activities in different tumors, alone or as an adjuvant with other antitumor drugs to prevent or inhibit the survival and cancer progression by various mechanisms. The role of curcumin in overcoming drug resistance was followed by reviewing different applications of curcumin in cancer therapy. Afterward, the clinical impacts of curcumin, role of curcumin in decreasing drug resistance in different cancer cells and its mechanisms were discussed. It has been demonstrated that curcumin regulates signaling pathways in cancer cells, reduces the expression of proteins related to drug resistance, and increases the performance of antitumor drugs at various levels. Curcumin reverses multidrug resistance mechanisms and increases sensitivity of resistance cells to chemotherapy. This review mainly focuses on different mechanisms of drug resistance and curcumin as a nontoxic natural substance to eliminate the effects of drug resistance through modulation and controlling cell resistance pathways and eventually suggests curcumin as a potent chemosensitizer in cancers.
化疗是癌症治疗的主要方法之一。然而，尽管抗癌药物的设计取得了许多进展，但由于其高毒性和细胞对化疗药物的耐药性，其效率受到限制。为了提高癌症治疗效果，必须使用能够克服耐药性并提高治疗效率的化合物。研究人员研究了天然化合物对控制各种耐药机制的影响。姜黄素是一种天然酚类化合物，在不同的肿瘤中具有很强的抗癌活性，单独使用或与其他抗肿瘤药物联合使用，通过多种机制预防或抑制肿瘤的存活和进展。通过回顾姜黄素在癌症治疗中的不同应用，研究了姜黄素在克服耐药性方面的作用。随后，讨论了姜黄素的临床影响、姜黄素在降低不同癌细胞耐药性中的作用及其机制。已经证明，姜黄素调节癌细胞中的信号通路，降低与耐药性相关的蛋白质的表达，并在多个层面上提高抗肿瘤药物的疗效。姜黄素逆转多药耐药机制，增加耐药细胞对化疗的敏感性。本综述主要关注不同的耐药机制和姜黄素作为一种无毒的天然物质，通过调节和控制细胞耐药途径来消除耐药性的影响，最终提出姜黄素作为癌症中有效的化疗增敏剂。
