Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul, Turkey.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
J Ocul Pharmacol Ther. 2020 Jul/Aug;36(6):342-354. doi: 10.1089/jop.2019.0135. Epub 2020 Apr 7.
Sufficient ophthalmic drug delivery is still challenging for pharmaceutical technologists, despite various scientific efforts. Several ocular drug carriers have been designed to enhance bioavailability by prolonging the drug retention time. One of the current encouraging approaches is the utilization of colloidal carriers with the characteristic submicron-nanometer size. Microemulsions (MEs) are such colloid systems that present sizes between 5 and 200 nm with significant thermodynamic stability and low surface tension. In addition, MEs as topical ocular carriers can lead to great ocular drug adsorption due to their enhanced retention time. Furthermore, considering that MEs are stable for long time and various temperatures, their ocular application is of great interest. The aim of this study is to cover basic physicochemical principals of ocular MEs such as their possible size, stability, and therapeutic efficacy against various eye disorders. Thus, a comprehensive review for ocular drug delivery systems in the form of MEs that show promising characteristics as their stability and therapeutic efficiency is performed.
尽管已经有了各种科学努力，但对于制药技术人员来说，仍然难以充分将药物输送到眼部。已经设计了几种眼部药物载体，通过延长药物滞留时间来提高生物利用度。目前令人鼓舞的方法之一是利用具有亚微米-纳米级特征的胶体载体。微乳液（MEs）就是这样的胶体系统，其粒径在 5 至 200nm 之间，具有显著的热力学稳定性和低表面张力。此外，由于 MEs 具有增强的滞留时间，因此作为局部眼部载体，它们可以导致药物在眼部的大量吸附。此外，考虑到 MEs 在长时间和各种温度下都稳定，因此它们的眼部应用非常有意义。本研究的目的是涵盖眼部 MEs 的基本物理化学原理，例如其可能的粒径、稳定性和对各种眼部疾病的治疗效果。因此，对以稳定性和治疗效果为特点的眼部药物传递系统进行了综述。
