静脉激光波长照射对糖尿病大鼠白细胞介素IL-1α、IL-1β、IL-6的影响
Intravenous Laser Wavelength Irradiation Effect on Interleukins: IL-1α, IL-1β, IL6 in Diabetic Rats.
作者信息
Amjadi A, Mirmiranpor H, Khandani S, Sobhani S O, Shafaee Y
机构信息
(Corresponding Author) Laser and Medical Physics Lab, Department of Physics, Sharif University of Technology, Tehran, Iran, E-mail:
Endocrinology and Metabolism Research Center (EMRC), Valiasr Hospital, School of Medicine, Tehran University of Medical Science, Tehran, Iran, E-mail:
出版信息
Laser Ther. 2019 Dec 31;28(4):267-273. doi: 10.5978/islsm.19-OR-18.
BACKGROUND AND AIMS
The main purpose of this investigation in Low-Level Laser Therapy (LLLT) on diabetic rats is laser wavelength effect on interleukins: IL-1α, IL-1β, IL6.
MATERIALS SUBJECTS AND METHODS
At first, diabetes was induced in Wistar rats by streptozotocin (STZ) injection. Then, by intravenous laser therapy, the rats were irradiated by four continuous wave lasers: IR (λ = 808 nm), Red (λ = 638 nm), Green (λ = 532 nm) and Blue (λ= 450 nm) to compare the related laser wavelength effect on different interleukins. The inflammatory parameters were measured 2,6 and 24 hours after laser therapy from blood samples and plotted for different laser wavelengths.
RESULTS
The results show a decrease in all the above parameters by different laser irradiation in comparison to non-radiated diabetic control ones. More importantly with constant laser energy as the laser wavelength decreases, it affects more efficiently on lowering the above parameters.
CONCLUSIONS
we can conclude from our data on diabetic rats that in intravenous LLLT, with constant laser energy, shorter wavelengths like Blue (λ= 450 nm) is more effective than longer wavelengths such as Red (λ = 638 nm) and IR (λ = 808 nm) lasers to lower the level of interleukins toward non-diabetic ones.
背景与目的
本研究对糖尿病大鼠进行低强度激光治疗（LLLT）的主要目的是探究激光波长对白细胞介素IL-1α、IL-1β、IL-6的影响。
材料、对象与方法：首先，通过注射链脲佐菌素（STZ）诱导Wistar大鼠患糖尿病。然后，采用静脉激光疗法，用四种连续波激光对大鼠进行照射：红外激光（λ = 808 nm）、红光激光（λ = 638 nm）、绿光激光（λ = 532 nm）和蓝光激光（λ = 450 nm），以比较不同激光波长对不同白细胞介素的影响。在激光治疗后2小时、6小时和24小时采集血样，测量炎症参数，并针对不同激光波长绘制图表。
结果
结果显示，与未接受照射的糖尿病对照组相比，不同激光照射后上述所有参数均有所降低。更重要的是，在激光能量恒定的情况下，随着激光波长的减小，其对降低上述参数的影响更有效。
结论
根据我们对糖尿病大鼠的数据可以得出结论，在静脉低强度激光治疗中，在激光能量恒定的情况下，较短波长的激光如蓝光激光（λ = 450 nm）比较长波长的激光如红光激光（λ = 638 nm）和红外激光（λ = 808 nm）更有效地降低白细胞介素水平，使其接近非糖尿病大鼠的水平。
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