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一种次生代谢产物与单纯疱疹病毒1型和2型糖蛋白受体的分子对接分析。

Molecular docking analysis of a secondary metabolite with the glycoprotein receptors of HSV 1 and HSV 2.

作者信息

Saran Natarajan, Anandharaj Balaiyah, Bupesh Giridharan, Vasanth Sakthivel, Beulah Joseph Pinto Jasmine, Balachandar Vellingiri

机构信息

Department of Virology, King Institute of Preventive Medicine and Research, Chennai, India.

Department of Microbiology, M.R. Government College, Mannargudi, India.

出版信息

Bioinformation. 2019 Dec 31;15(12):887-895. doi: 10.6026/97320630015887. eCollection 2019.

DOI:10.6026/97320630015887
PMID:32256009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7088423/
Abstract

Herpes simplex viruses (HSV) are alpha herpes viruses, which causes life-threatening illness. Therefore, it is of interest to design and develop potential drugs to treat HSV infections. We show the optimal molecular docking properties of a secondary metabolite (3, 7, 11, 15 tetra methyl-2-2-hexadecen-'1-ol) with the glycoprotein receptors of HSV1 and HSV 2 for further consideration.

摘要

单纯疱疹病毒（HSV）是α疱疹病毒，可引发危及生命的疾病。因此，设计和开发治疗HSV感染的潜在药物具有重要意义。我们展示了一种次生代谢产物（3,7,11,15-四甲基-2-十六碳烯-1-醇）与HSV1和HSV2糖蛋白受体的最佳分子对接特性，以供进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/fdb4b85baaf5/97320630015887F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/06ee64e59ce5/97320630015887F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/a1e940a5c010/97320630015887F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/b60eecacdcf1/97320630015887F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/22094e286c5d/97320630015887F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/fdb4b85baaf5/97320630015887F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/06ee64e59ce5/97320630015887F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/a1e940a5c010/97320630015887F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/b60eecacdcf1/97320630015887F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/22094e286c5d/97320630015887F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b0/7088423/fdb4b85baaf5/97320630015887F5.jpg

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