Iyer Maithreyi Suresh, Abhinand P A, Hemalatha C R
Department of Bioinformatics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai-600 116, India.
Bioinformation. 2019 Dec 31;15(12):918-921. doi: 10.6026/97320630015918. eCollection 2019.
Catheter-associated urinary tract infections (CAUTIs) caused by biofilms on indwelling medical devices are the most common type of nosocomial infections, a major health concern due to complications and frequent recurrence. The infections are most often caused by Escherichia coli. Curli are proteinaceous components of a complex extracellular matrix produced by various strains of Enterobacteriaceae. Curli fibers are involved with adhesion to surfaces, cell aggregation and biofilm formation. Therefore, it is of interest to study the protein interactions in curli biogenesis, identifying proteins involved in curli biogenesis, the interactions and development of a combinatorial library of novel lead molecules against biofilm formation by Escherichia coli. Targeting the CsgG protein of Escherichia coli could provide new treatment modalities to fight CAUTIs, better. This study may also help study infections caused by various strains of Enterobacteriaceae, in general.
由留置医疗设备上的生物膜引起的导管相关尿路感染（CAUTIs）是最常见的医院感染类型，由于并发症和频繁复发，这是一个主要的健康问题。这些感染最常由大肠杆菌引起。卷曲菌毛是由各种肠杆菌科菌株产生的复杂细胞外基质的蛋白质成分。卷曲菌毛纤维参与表面粘附、细胞聚集和生物膜形成。因此，研究卷曲菌毛生物合成中的蛋白质相互作用、鉴定参与卷曲菌毛生物合成的蛋白质、相互作用以及开发针对大肠杆菌生物膜形成的新型先导分子组合文库具有重要意义。靶向大肠杆菌的CsgG蛋白可以更好地提供对抗CAUTIs的新治疗方式。总体而言，这项研究也可能有助于研究各种肠杆菌科菌株引起的感染。
