靶向微生物生物膜：当前及未来的治疗策略
Targeting microbial biofilms: current and prospective therapeutic strategies.
作者信息
Koo Hyun, Allan Raymond N, Howlin Robert P, Stoodley Paul, Hall-Stoodley Luanne
机构信息
Biofilm Research Laboratories, Levy Center for Oral Health, Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Pennsylvania 19104-6030, USA.
Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
出版信息
Nat Rev Microbiol. 2017 Dec;15(12):740-755. doi: 10.1038/nrmicro.2017.99. Epub 2017 Sep 25.
Abstract
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections. The multifactorial nature of biofilm development and drug tolerance imposes great challenges for the use of conventional antimicrobials and indicates the need for multi-targeted or combinatorial therapies. In this Review, we focus on current therapeutic strategies and those under development that target vital structural and functional traits of microbial biofilms and drug tolerance mechanisms, including the extracellular matrix and dormant cells. We emphasize strategies that are supported by in vivo or ex vivo studies, highlight emerging biofilm-targeting technologies and provide a rationale for multi-targeted therapies aimed at disrupting the complex biofilm microenvironment.
摘要
生物膜形成是多种导致慢性感染的微生物的关键毒力因子。生物膜形成和耐药性的多因素性质给传统抗菌药物的使用带来了巨大挑战，并表明需要多靶点或联合疗法。在本综述中，我们重点关注当前针对微生物生物膜的重要结构和功能特征以及耐药机制（包括细胞外基质和休眠细胞）的治疗策略和正在开发的策略。我们强调那些得到体内或体外研究支持的策略，突出新兴的生物膜靶向技术，并为旨在破坏复杂生物膜微环境的多靶点疗法提供理论依据。
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