Roth R P, Cantekin E I, Bluestone C D, Welch R M, Cho Y W
Ann Otol Rhinol Laryngol. 1977 Mar-Apr;86(2 pt. 1):235-42. doi: 10.1177/000348947708600216.
The effectiveness of orally administered pseudoephedrine in patients with acute or chronic nonsuppurative rhinitis was evaluated under double-blind conditions. Intranasally administered ephedrine which was given to all patients at the end of this study served as the positive control. Marked nasal decongestant effects of a single oral dose of pseudoephedrine (60 mg tablet), as determined by a modified passive anterior, rhinometric technique occurred within 30 minutes and were maintained for at least four hours. The mean nasal decongestant response (delta % of baseline) of 57.2% was associated with a mean peak, plasma pseudoephedrine level of 274 ng/ml. In addition, the maximum response to oral pseudoephedrine treatment was equivalent to the response produced by ephedrine nasal spray. These results suggest that pseudoephedrine is an orally, effective nasal decongestant.
在双盲条件下评估了口服伪麻黄碱对急慢性非化脓性鼻炎患者的疗效。在本研究结束时给予所有患者的鼻内用麻黄碱作为阳性对照。采用改良的被动前鼻测压技术测定，单次口服伪麻黄碱（60毫克片剂）后30分钟内出现明显的鼻减充血作用，并至少维持4小时。平均鼻减充血反应（相对于基线的变化百分比）为57.2%，平均伪麻黄碱血浆峰值水平为274纳克/毫升。此外，口服伪麻黄碱治疗的最大反应等同于麻黄碱鼻喷雾剂产生的反应。这些结果表明伪麻黄碱是一种有效的口服鼻减充血剂。
