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磷霉素-美罗培南及磷霉素-黏菌素对碳青霉烯类耐药菌的协同活性：一项证据

Synergistic activity of fosfomycin-meropenem and fosfomycin-colistin against carbapenem resistant : an evidence.

作者信息

Bakthavatchalam Yamuna Devi, Shankar Abirami, Muthuirulandi Sethuvel Dhiviya Prabaa, Asokan Kalaiarasi, Kanthan Kalaiarasi, Veeraraghavan Balaji

机构信息

Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.

出版信息

Future Sci OA. 2020 Feb 26;6(4):FSO461. doi: 10.2144/fsoa-2019-0074.

DOI:10.2144/fsoa-2019-0074
PMID:32257374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7117555/
Abstract

AIM

To evaluate the antibacterial activity of fosfomycin-meropenem and fosfomycin-colistin combinations against carbapenem-resistant (CR-Kp).

METHODS

A total of 50 CR-Kp isolates recovered from blood cultures were included in this study. All the CR-Kp isolates were screened for the presence of carbapenem resistant genes . . . like, . .#x00A0;and . Combination testing of fosfomycin-meropenem and fosfomycin-colistin were performed using time-kill assay.

RESULTS

Fosfomycin-meropenem combination showed synergy in 20% of the tested CR-Kp isolates. While, fosfomycin-colistin exhibited synergy against 16% of the isolates. A total of 68% (n = 34) of CR-Kp isolates were characterised as OXA-48-like producers and 22% (n = 11) as NDM producers. Synergistic activity of these combinations was observed against OXA-48, NDM and NDM + OXA-48 co-producers.

CONCLUSION

Considerable synergistic antibacterial activity of fosfomycin-meropenem and fosfomycin-colistin was not observed against CR-Kp isolates. Therefore, these combinations may not be promising for infections associated with CR-Kp.

摘要

目的

评估磷霉素-美罗培南及磷霉素-黏菌素联合用药对耐碳青霉烯类肺炎克雷伯菌（CR-Kp）的抗菌活性。

方法

本研究纳入了从血培养中分离出的50株CR-Kp菌株。对所有CR-Kp菌株进行碳青霉烯耐药基因……如……和……的筛查。采用时间杀菌试验对磷霉素-美罗培南及磷霉素-黏菌素进行联合检测。

结果

磷霉素-美罗培南联合用药在20%的受试CR-Kp菌株中显示出协同作用。而磷霉素-黏菌素对16%的菌株表现出协同作用。共有68%（n = 34）的CR-Kp菌株被鉴定为OXA-48样产酶株，22%（n = 11）为NDM产酶株。观察到这些联合用药对OXA-48、NDM及NDM + OXA-48共产生菌株具有协同活性。

结论

未观察到磷霉素-美罗培南及磷霉素-黏菌素对CR-Kp菌株有显著的协同抗菌活性。因此，这些联合用药对与CR-Kp相关的感染可能没有前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afb/7117555/b4ff82fa8f1a/fsoa-06-461-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afb/7117555/4e3b0438d299/fsoa-06-461-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afb/7117555/b4ff82fa8f1a/fsoa-06-461-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afb/7117555/4e3b0438d299/fsoa-06-461-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afb/7117555/b4ff82fa8f1a/fsoa-06-461-g2.jpg

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