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法国大肠杆菌分离株中质粒介导的磷霉素抗性基因的出现

Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France.

作者信息

Benzerara Yahia, Gallah Salah, Hommeril Baptiste, Genel Nathalie, Decré Dominique, Rottman Martin, Arlet Guillaume

出版信息

Emerg Infect Dis. 2017 Sep;23(9):1564-1567. doi: 10.3201/eid2309.170560.

DOI:10.3201/eid2309.170560
PMID:28820368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5572872/
Abstract

FosA, a glutathione S-transferase that inactivates fosfomycin, has been reported as the cause of enzymatic resistance to fosfomycin. We show that multiple lineages of FosA-producing extended spectrum β-lactamase Escherichia coli have circulated in France since 2012, potentially reducing the efficacy of fosfomycin in treating infections with antimicrobial drug-resistant gram-negative bacilli.

摘要

FosA是一种可使磷霉素失活的谷胱甘肽S-转移酶，已被报道为磷霉素酶促耐药的原因。我们发现，自2012年以来，产生FosA的超广谱β-内酰胺酶大肠杆菌的多个谱系在法国传播，这可能会降低磷霉素治疗耐抗菌药物革兰氏阴性杆菌感染的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a49/5572872/65fe32c8ad37/17-0560-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a49/5572872/65fe32c8ad37/17-0560-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a49/5572872/65fe32c8ad37/17-0560-F.jpg

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