关于来自儿科患者的耐甲氧西林金黄色葡萄球菌（MRSA）分离株的抗生素耐药模式

Antibiotic resistance pattern of with reference to MRSA isolates from pediatric patients.

作者信息

Gurung Raja Ram, Maharjan Prashanna, Chhetri Ganga Gharti

机构信息

Tri-Chandra Multiple Campus affiliated to Tribhuvan University, Department of Microbiology, Kirtipur, Kathmandu 44600, Nepal.

Biotechnology Society of Nepal (BSN), Rani Devi Marg, Kathmandu 44600, Nepal.

出版信息

Future Sci OA. 2020 Feb 24;6(4):FSO464. doi: 10.2144/fsoa-2019-0122.

AIM

The extent of methicillin-resistant (MRSA) infection in Nepalese children is largely unknown.

MATERIALS & METHODS: Six hundred and seventy-two clinical samples collected from 232 patients between June and November 2016 were processed in a microbiology laboratory.

RESULTS

Out of 300 culture-positive samples, 52 (17.3%) were isolates. Among those 52, 39 (75.0%) were found to be MRSA. The infection rate of was shown to be higher in inpatients (55.7%) compared with outpatients (44.3%) at p = 0.637, 95% CI. Thirteen types of antibiotics were used in the antibiotic susceptibility test. MRSA isolates showed 100 and 0% resistance to penicillin and vancomycin, respectively. The D-test showed inducible clindamycin-resistant phenotype in 15.4% of MRSA isolates.

CONCLUSION

This demonstrates the utmost need for routine testing for MRSA in Nepalese hospitals.

目的

尼泊尔儿童耐甲氧西林金黄色葡萄球菌（MRSA）感染的程度很大程度上未知。

材料与方法

2016年6月至11月期间从232名患者收集的672份临床样本在微生物实验室进行处理。

结果

在300份培养阳性样本中，有52份（17.3%）为分离株。在这52份中，发现39份（75.0%）为MRSA。在p = 0.637、95%置信区间的情况下，住院患者的MRSA感染率（55.7%）高于门诊患者（44.3%）。在抗生素敏感性试验中使用了13种抗生素。MRSA分离株对青霉素和万古霉素的耐药率分别为100%和0%。D试验显示15.4%的MRSA分离株具有诱导型克林霉素耐药表型。