Natrajsetty Huliyurdurga S Setty, Vijayalakshmi Ishwarappa B, Narasimhan Chitra, Manjunath Cholenahalli N
Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, India.
Am J Case Rep. 2015 Apr 23;16:236-9. doi: 10.12659/AJCR.893072.
Infective endocarditis (IE) is a disease with a highly varied clinical picture. Spread of the infection to the pericardium from the infective endocardium is uncommon and IE involving all 4 cardiac valves is also a very rare occurrence, being more common in intravenous drug users (IVDU).
A 7-year-old boy had purulent pericarditis with infective endocarditis (IE) on all 4 cardiac valves and vegetation in the left ventricular and right atrial cavity. Culture of the pericardial fluid grew methicillin-resistant staphylococcus aureus (MRSA) sensitive to tigecycline. The child made a dramatic improvement with tigecycline treatment.
Aggressive management with pericardiocentesis and appropriate antibiotics can show remarkable clinical improvement. Tigecycline can be used safely and effectively as a life-saving drug in children.
感染性心内膜炎（IE）是一种临床表现高度多样的疾病。感染从感染性心内膜蔓延至心包并不常见，累及所有4个心脏瓣膜的IE更是极为罕见，在静脉注射毒品者（IVDU）中较为常见。
一名7岁男孩患有化脓性心包炎，同时累及所有4个心脏瓣膜的感染性心内膜炎（IE），且左心室和右心房腔内有赘生物。心包液培养出对替加环素敏感的耐甲氧西林金黄色葡萄球菌（MRSA）。该患儿经替加环素治疗后显著好转。
积极进行心包穿刺引流及使用恰当抗生素治疗可使临床症状显著改善。替加环素可作为儿童救命药物安全有效地使用。
