Sorkness Christine A, Scholl Linda, Fair Alecia M, Umans Jason G
Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI, USA.
Meharry-Vanderbilt Alliance, Nashville, TN, USA.
J Clin Transl Sci. 2019 Dec 26;4(1):43-52. doi: 10.1017/cts.2019.424. eCollection 2020 Feb.
NIH Clinical and Translational Science Awards (CTSAs) include KL2 mentored career development awards for faculty commencing clinical and translational research. A survey of KL2 leaders revealed program practices, curricular elements and compelling data about scholar characteristics and outcomes.
We conducted a literature review, framed the survey construct, and obtained input from across the CTSA consortium. A REDCap survey was emailed in fall 2016 to 61 active programs.
Fifty-five programs (90.2%) responded. Respondents had been funded from 3 to 11 years, including 22 "mature" hubs funded for ≥8 years. Program cohort sizes were 56% "small", 22% "medium", and 22% "large." Hubs offer extensive competency-aligned training opportunities relevant to clinical and translational research, including graduate degrees, mentorship, and grant-writing. Seventy-two percent of hubs report parallel "KL2-equivalent" career development programs. All hubs share their training and facilitate intermingling with other early stage investigators. A total of 1,517 KL2 scholars were funded. KL2 awardees are diverse in their disciplines, research projects, and representation; 54% are female and 12% self-identified as underrepresented in biomedical research. Eighty-seven percent of scholars have 2-3 mentors and are currently supported for 2-3 years. Seventy-eight percent of alumni remain at CTSA institutions in translational science. The most common form of NIH support following scholars' KL2 award is an individual career development award.
The KL2 is a unique career development award, shaped by competency-aligned training opportunities and interdisciplinary mentorship that inform translational research pathways. Tracking both traditional and novel outcomes of KL2 scholars is essential to capture their career trajectories and impact on health.
美国国立卫生研究院临床与转化科学奖（CTSA）包括为开展临床与转化研究的教职人员设立的KL2指导型职业发展奖。对KL2负责人的一项调查揭示了项目实践、课程要素以及有关学者特征和成果的令人信服的数据。
我们进行了文献综述，构建了调查架构，并从CTSA联盟各地获取了意见。2016年秋季，通过REDCap向61个活跃项目发送了调查问卷。
55个项目（90.2%）做出了回应。受访者获得资助的时间为3至11年，其中包括22个获得资助≥8年的“成熟”中心。项目队列规模为56%“小”、22%“中”和22%“大”。中心提供与临床和转化研究相关的广泛的能力匹配培训机会，包括研究生学位、指导和资助撰写。72%的中心报告有并行的“KL2等效”职业发展项目。所有中心都分享他们的培训，并促进与其他早期研究人员的交流。共有1517名KL2学者获得资助。KL2获奖者在学科、研究项目和代表性方面各不相同；54%为女性，12%自我认定在生物医学研究中代表性不足。87%的学者有2至3名导师，目前获得2至3年的支持。78%的校友仍留在CTSA机构从事转化科学工作。学者获得KL2奖后，美国国立卫生研究院最常见的支持形式是个人职业发展奖。
KL2是一项独特的职业发展奖，由能力匹配的培训机会和跨学科指导塑造，这些为转化研究路径提供了信息。追踪KL2学者的传统和新成果对于了解他们的职业轨迹及其对健康的影响至关重要。
