Alraei Kamel, Sharqawi Jameel, Harcher Somaya, Ghita Ibrahim
Department of Oral and Maxillofacial Surgery, Al-Noor Specialist Hospital, Makkah, Saudi Arabia.
Department of Oral and Maxillofacial Surgery, Royal Commission Hospital, Jubail, Saudi Arabia.
Case Rep Dent. 2020 Mar 18;2020:8281741. doi: 10.1155/2020/8281741. eCollection 2020.
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive growth factor used in oral and maxillofacial surgery. It offers a feasible alternative for various regenerative procedures, including reconstruction of mandibular defects. In this study, we report a case of a large Pindborg tumor involving the left mandible. The treatment consisted of surgical resection, followed by off-label use of rhBMP-2 in addition to bone marrow aspirate concentrate, together with an allograft in a titanium mesh. The patient was rehabilitated with dental implants, and a good clinical outcome was achieved. We found no evidence of bone resorption or complications in both clinical and radiographic evaluations during the one-year follow-up period. In conclusion, we have demonstrated the efficacy of using rhBMP-2 combined with bone marrow aspirate concentrate, and an allograft with a titanium mesh, for the reconstruction of long mandibular bone defects. Not only is this combination feasible, but it also has the advantages of lower morbidity and cost.
重组人骨形态发生蛋白-2（rhBMP-2）是一种用于口腔颌面外科的骨诱导生长因子。它为包括下颌骨缺损重建在内的各种再生手术提供了一种可行的替代方案。在本研究中，我们报告了一例累及左下颌骨的大型平斯堡瘤病例。治疗包括手术切除，随后除了使用浓缩骨髓抽吸物外，还超适应证使用rhBMP-2，并在钛网中植入同种异体骨。患者通过牙种植体进行了修复，取得了良好的临床效果。在一年的随访期内，我们在临床和影像学评估中均未发现骨吸收或并发症的证据。总之，我们已经证明了使用rhBMP-2联合浓缩骨髓抽吸物以及钛网同种异体骨重建下颌骨长节段骨缺损的有效性。这种联合不仅可行，而且具有发病率低和成本低的优点。
