Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, China.
Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China.
Biomed Res Int. 2020 Mar 11;2020:3475289. doi: 10.1155/2020/3475289. eCollection 2020.
Abdominal wall weakness occurs when the strength of muscle decreases due to physiological reason or iatrogenic injury. However, the treatment of this disease is complicated.
To study the therapeutic effect of acellular tissue matrix (ACTM), compared with the polypropylene mesh.
An abdominal wall weakness model was established in rabbits through motor nerves cutting. The polypropylene mesh and ACTM were implanted in the left and right abdomen sides, respectively. Mechanical testing of abdominal wall muscle and histology and scanning electron microscopy (SEM) evaluation of abdominal tissue explants were performed.
In animal model establishment, the abdominal length of healthy and weakened abdominal wall was 17.0 ± 0.7 cm and 19.0 ± 1.2 cm, respectively (=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (.
The abdominal wall weakness model in rabbits was successfully established. ACTM is a promising biological material to be possibly further applied in clinical surgery in patients with abdominal wall weakness.
腹壁薄弱是由于生理原因或医源性损伤导致肌肉力量下降而发生的。然而，这种疾病的治疗很复杂。
研究去细胞组织基质（ACTM）与聚丙烯网片相比的治疗效果。
通过切断运动神经在兔中建立腹壁薄弱模型，分别将聚丙烯网片和 ACTM 植入左右腹部。对腹壁肌肉进行力学测试，对腹部组织标本进行组织学和扫描电子显微镜（SEM）评估。
在动物模型建立中，健康腹壁和薄弱腹壁的腹长分别为 17.0±0.7cm 和 19.0±1.2cm（=0.022），薄弱腹壁组的拉伸应力显著下降 1.116±0.221MPa（=0.022），并且薄弱腹壁组的最大拉伸强度显著下降 1.026±0.164MPa（=0.022）。
兔腹壁薄弱模型成功建立。ACTM 是一种有前途的生物材料，可能进一步应用于腹壁薄弱患者的临床手术。
