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早期糖尿病性周围神经病降低足部力量和内在但不外在足部肌肉大小。

Early-Stage Diabetic Neuropathy Reduces Foot Strength and Intrinsic but Not Extrinsic Foot Muscle Size.

机构信息

Exercise Sciences Department, Brigham Young University, Provo, UT, USA.

出版信息

J Diabetes Res. 2020 Mar 12;2020:9536362. doi: 10.1155/2020/9536362. eCollection 2020.

Abstract

BACKGROUND

Tracking progression of diabetic peripheral polyneuropathy (DPN) is usually focused on sensory nerves and subjective testing methods. Recent studies have suggested that distal muscle atrophy may precede sensation loss. Methods to objectively measure distal muscle size and strength are needed to help understand how neuropathy affects muscle function.

PURPOSE

To evaluate individual intrinsic and extrinsic foot muscle sizes and functional foot strength in participants with DPN.

METHODS

Thirty individuals participated in this cross-sectional study (15 DPN and 15 matched controls). Sizes of 10 separate muscles of the lower leg and foot were measured using ultrasound imaging. Functional foot strength was also quantified using custom great toe and lateral toe flexion tests along with a doming test. Muscle size and strength metrics were compared between groups using ANOVAs and paired -tests ( = 0.05). Correlations between strength and relevant muscle sizes were also evaluated.

RESULTS

The sizes of all four intrinsic foot muscles were smaller in individuals with DPN ( ≤ 0.03), while only one (toe extensor) of the six extrinsic muscles was smaller ( ≤ 0.03), while only one (toe extensor) of the six extrinsic muscles was smaller ( ≤ 0.03), while only one (toe extensor) of the six extrinsic muscles was smaller ( ≤ 0.03), while only one (toe extensor) of the six extrinsic muscles was smaller ( ≤ 0.80) with several corresponding intrinsic muscle sizes. The doming strength test did not show any difference between groups and was moderately correlated with one muscle size ( ≤ 0.80) with several corresponding intrinsic muscle sizes. The doming strength test did not show any difference between groups and was moderately correlated with one muscle size (.

CONCLUSION

Diabetic peripheral polyneuropathy affects intrinsic muscles before extrinsics. Ultrasound imaging of individual muscles and functional toe flexion tests can be used clinically to monitor DPN progression and foot function. Participants need to be trained in the doming test before a relationship can be established between this test and DPN foot function. Future studies should include muscle quality measurements to better understand characteristics of affected muscles.

摘要

背景

跟踪糖尿病周围神经病变(DPN)的进展通常集中在感觉神经和主观测试方法上。最近的研究表明,远端肌肉萎缩可能先于感觉丧失。需要客观测量远端肌肉大小和力量的方法来帮助了解神经病变如何影响肌肉功能。

目的

评估 DPN 患者个体内在和外在足部肌肉的大小和功能性足部力量。

方法

30 名参与者参与了这项横断面研究(15 名 DPN 患者和 15 名匹配的对照组)。使用超声成像测量小腿和足部的 10 块单独肌肉的大小。还使用定制的大脚趾和外侧脚趾弯曲测试以及穹顶测试来量化功能性足部力量。使用 ANOVA 和配对检验( = 0.05)比较组间的肌肉大小和力量指标。还评估了强度与相关肌肉大小之间的相关性。

结果

DPN 患者的所有 4 块内在足部肌肉的大小都较小( ≤ 0.03),而 6 块外在肌肉中只有 1 块(趾伸肌)较小( ≤ 0.03),而 6 块外在肌肉中只有 1 块(趾伸肌)较小( ≤ 0.03),而 6 块外在肌肉中只有 1 块(趾伸肌)较小( ≤ 0.03),而 6 块外在肌肉中只有 1 块(趾伸肌)较小( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。穹顶强度测试在组间没有显示任何差异,并且与一个肌肉大小中度相关( ≤ 0.80),而几个相应的内在肌肉大小。

结论

糖尿病周围神经病变先影响内在肌肉,然后影响外在肌肉。个体肌肉的超声成像和功能性脚趾弯曲测试可用于临床监测 DPN 的进展和足部功能。在建立穹顶测试与 DPN 足部功能之间的关系之前,参与者需要接受穹顶测试的培训。未来的研究应包括肌肉质量测量,以更好地了解受影响肌肉的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa94/7091556/659dc174d43b/JDR2020-9536362.001.jpg

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