Department of Human Anatomy, Faculty of Medicine & Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Department of Medicine, Faculty of Medicine & Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
J Immunol Res. 2020 Mar 9;2020:9469210. doi: 10.1155/2020/9469210. eCollection 2020.
Alzheimer's disease (AD) has been clinically characterized by a progressive degeneration of neurons which resulted in a gradual and irreversible cognitive impairment. The accumulation of A and proteins in the brain contribute to the severity of the disease. Recently, vitexin compound has been the talk amongst researchers due to its pharmacological properties as anti-inflammation and anti-AD. However, the epigenetic mechanism of the compound in regulating the neuroinflammation activity is yet to be fully elucidated. Hence, this review discusses the potential of vitexin compound to have the pharmacoepigenetic property in regulating the neuroinflammation activity in relation to AD. It is with hope that the review would unveil the potential of vitexin as the candidate in treating AD.
阿尔茨海默病（AD）在临床上以神经元的进行性退化为特征，导致认知障碍逐渐加重且不可逆转。大脑中 A 和 蛋白的积累导致了疾病的严重程度。最近，牡荆素化合物因其具有抗炎和抗 AD 的药理学特性而成为研究人员关注的焦点。然而，该化合物在调节神经炎症活性方面的表观遗传机制尚未完全阐明。因此，本综述讨论了牡荆素化合物在调节 AD 相关神经炎症活性方面具有药物表观遗传特性的潜力。希望本综述能揭示牡荆素作为治疗 AD 候选药物的潜力。
