Thi Thu Nguyen Trang, Shang Enyuan, Karpel-Massler Georg, Siegelin Markus D
Department of Pathology & Cell Biology, Columbia University Medical Center, New York, New York, USA.
Department of Biological Sciences, Bronx Community College, City University of New York, Bronx, New York, USA.
Oncoscience. 2020 Mar 20;7(1-2):14-16. doi: 10.18632/oncoscience.498. eCollection 2020 Jan.
The elucidation of better treatments for solid tumors and especially malignant glial tumors is a priority. Better understanding of the molecular underpinnings of treatment response and resistance are critical determinants in the success for this endeavor. Recently, a battery of novel tools have surfaced that allow to interrogate tumor cell metabolism to more precise extent than this was possible in the earlier days. At the forefront of these developments are the extracellular flux and carbon tracing analyses. Through utilization of these techniques our group made the recent observation that acute and chronic c-MET inhibition drives fatty acid oxidation that in turn can be therapeutically targeted for drug combination therapies. Herein, we summarize and comment on some of our key findings related to this study.
阐明针对实体瘤尤其是恶性胶质细胞瘤的更好治疗方法是当务之急。更好地理解治疗反应和耐药性的分子基础是这一努力取得成功的关键决定因素。最近，一系列新颖的工具出现了，它们能够比早期更精确地探究肿瘤细胞代谢。这些进展的前沿是细胞外通量和碳追踪分析。通过利用这些技术，我们团队最近观察到，急性和慢性c-MET抑制会驱动脂肪酸氧化，而脂肪酸氧化反过来又可作为联合药物治疗的治疗靶点。在此，我们总结并评论与本研究相关的一些关键发现。
