Badiyan Shahed, Kaiser Adeel, Eastman Bory, Forsthoefel Matthew, Zeng Jing, Unger Keith, Chuong Michael
Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
University of Maryland Medical Center, Baltimore, MD, USA.
Transl Gastroenterol Hepatol. 2020 Apr 5;5:21. doi: 10.21037/tgh.2019.10.07. eCollection 2020.
Immunotherapy represents the newest pillar in cancer care. Although there are increasing data showing the efficacy of immunotherapy there is a spectrum of response across unselected populations of cancer patients. In fact, response rates can be poor even among patients with immunogenic tumors for reasons that remain poorly understood. A promising clinical strategy to improve outcomes, which is supported by an abundance of preclinical data, is combining immunotherapy with radiation therapy. Here we review the existing evidence and future directions for combining immunotherapy and radiation therapy for patients with gastrointestinal cancers.
免疫疗法是癌症治疗领域最新的支柱。尽管越来越多的数据表明免疫疗法的疗效，但在未经挑选的癌症患者群体中，反应存在差异。事实上，即使在具有免疫原性肿瘤的患者中，反应率也可能很低，原因仍不清楚。大量临床前数据支持的一种有望改善治疗效果的临床策略是将免疫疗法与放射疗法相结合。在此，我们综述了免疫疗法与放射疗法联合用于胃肠道癌症患者的现有证据和未来方向。
