Monteiro Catarina, Costa Ana Rute, Peleteiro Bárbara
EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal.
Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine, University of Porto, Porto, Portugal.
Porto Biomed J. 2016 May-Jun;1(2):52-58. doi: 10.1016/j.pbj.2016.05.001. Epub 2016 Jun 17.
was observed in 30% of children and 26% had excessive sodium intake.No association was found between sodium intake and infection in early life.This is the first study testing sodium effect in infection in children.
infection is mainly acquired during childhood and is associated with an increased risk of developing gastric cancer. High amounts of sodium intake can lead to the onset of pre-malignant lesions contributing to the process of carcinogenesis, and potentiate the effect of infection. This study aimed to evaluate the exposure to sodium in children until 4 years of age and to quantify its association with infection.
This study includes 503 children from the cohort Generation XXI, recruited after childbirth and re-evaluated at 6 months and at 4 years of age. Information about socio-demographic characteristics, food intake after birth and status of infection (assessed by serum ELISA) was collected. Scores of sodium exposure were calculated using the consumption of milk and other food items (evaluated at 6 months), and food items with the highest contribution to sodium intake and sodium intake (evaluated at 4 years). Logistic regression models were used to compute adjusted odds ratio (OR) and respective 95% confidence intervals (CI).
We found that 28.2% of children were infected with at 4 years of age, with a daily sodium intake that exceeded World Health Organization recommendations in 26%. No statistically significant association between sodium intake and infection was observed, with the exception of the 2nd quarter in the score concerning consumption of "other food items" in the assessment at 6 months of age (OR = 2.41; 95%CI: 1.29-4.50).
No association between sodium intake and infection was found; however, to the best of our knowledge, the present epidemiologic study is the first to test the influence of sodium intake in infection in children.
在30%的儿童中观察到[具体情况未提及]，26%的儿童钠摄入量过高。未发现钠摄入量与儿童早期感染之间存在关联。这是第一项测试钠对儿童感染影响的研究。
[具体感染名称未提及]主要在儿童期获得，并且与患胃癌风险增加有关。高钠摄入量可导致癌前病变的发生，促进致癌过程，并增强[具体感染名称未提及]感染的影响。本研究旨在评估4岁以下儿童的钠暴露情况，并量化其与[具体感染名称未提及]感染的关联。
本研究纳入了来自二十一世纪队列的503名儿童，这些儿童在出生后被招募，并在6个月和4岁时进行重新评估。收集了社会人口学特征、出生后食物摄入情况以及[具体感染名称未提及]感染状况（通过血清ELISA评估）的信息。使用牛奶和其他食物的消费量（在6个月时评估）以及对钠摄入量贡献最大的食物项目和钠摄入量（在4岁时评估）来计算钠暴露分数。使用逻辑回归模型计算调整后的优势比（OR）和相应的95%置信区间（CI）。
我们发现，4岁时28.2%的儿童感染了[具体感染名称未提及]，26%的儿童每日钠摄入量超过了世界卫生组织的建议。除了在6个月龄评估中关于“其他食物项目”消费得分的第二季度外，未观察到钠摄入量与[具体感染名称未提及]感染之间存在统计学上的显著关联（OR = 2.41；95%CI：1.29 - 4.50）。
未发现钠摄入量与[具体感染名称未提及]感染之间存在关联；然而，据我们所知，本流行病学研究是第一项测试钠摄入量对儿童[具体感染名称未提及]感染影响的研究。
