Epidemiological study of Helicobacter pylori infection and its association with gastric carcinogenesis.

INTRODUCTION

Helicobacter pylori (H.pylori) infection is recognized as a worldwide problem, mainly in developing countries where infection reaches 80% of the population. H.pylori is associated with various gastric diseases, mainly, many benign, premalignant and malignant lesions of the gastric mucosa. The aim of our study was to determine the prevalence of H.pylori infection and to highlight the determinants of the infection as well as the gastric lesions associated with this bacterium in a Moroccan population.

PATIENTS AND METHODS

A total of 162 asymptomatic subjects collected from Casablanca blood transfusion, and 254 patients suffering from various gastric lesions collected from gastroenterology and oncology services of the IbnRochd CHU, were targeted typing of gastric lesionsand H.pylori status were performed by Histological examination and ELISA test.

RESULTS

Our results showed a high prevalence of H. pylori infection in asymptomatic and gastric diseases patients. We noticed that the worsening of gastric lesions related to H.pylori infection increases with age, and it was influenced bytobacco consumption and the living area.

CONCLUSION

Our study showed that gastric cancer was more occurred in rural areas than in urban areas.It is necessary to update the recommendations regarding diagnosis, treatment of H. pylori infection and follow-up of the patients to avoid the evolution of simple chronic gastritis to gastric cancer.