抗氧化药物“U-74389G”对大鼠缺氧复氧损伤期间平均血小板体积水平的急性影响。
The acute effect of the antioxidant drug "U-74389G" on mean platelet volume levels during hypoxia reoxygenation injury in rats.
作者信息
Tsompos C, Panoulis C, Toutouzas K, Triantafyllou A, Zografos G, Papalois A
机构信息
Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece.
Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece.
出版信息
Porto Biomed J. 2016 Nov-Dec;1(5):186-190. doi: 10.1016/j.pbj.2016.10.003. Epub 2016 Nov 9.
BACKGROUND
This experimental study examined the effect of the antioxidant drug "U-74389G", on a rat model and particularly in a hypoxia - reoxygenation protocol. The effects of that molecule were studied hematologically using blood mean platelets volume (MPV) levels.
METHODS
40 rats of mean weight 231.875 g were used in the study. MPV levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D). The drug U-74389G was administered only in groups C and D.
RESULTS
U-74389G administration kept significantly increased the predicted MPV levels by 12.77 ± 3.07% ( = 0.0001). Reoxygenation time non-significantly decreased the predicted MPV levels by 2.55 ± 3.71% ( = 0.4103). However, U-74389G administration and reoxygenation time together kept significantly increased the predicted MPV levels by 7.09 ± 1.91% ( = 0.0005).
CONCLUSIONS
U-74389G administration whether it interacted or not with reoxygenation time kept significantly increased the predicted MPV levels. This finding has great clinical interest in blood clotting and coagulation pathophysiology.
背景
本实验研究检测了抗氧化药物“U - 74389G”对大鼠模型的影响，特别是在缺氧 - 复氧实验方案中的影响。使用血液平均血小板体积（MPV）水平从血液学角度研究了该分子的作用。
方法
本研究使用了40只平均体重为231.875克的大鼠。在复氧60分钟时（A组和C组）以及复氧120分钟时（B组和D组）测量MPV水平。仅在C组和D组中给予药物U - 74389G。
结果
给予U - 74389G可使预测的MPV水平显著升高12.77±3.07%（P = 0.0001）。复氧时间使预测的MPV水平非显著降低2.55±3.71%（P = 0.4103）。然而，给予U - 74389G与复氧时间共同作用可使预测的MPV水平显著升高7.09±1.91%（P = 0.0005）。
结论
无论是否与复氧时间相互作用，给予U - 74389G均可使预测的MPV水平显著升高。这一发现对血液凝固和凝血病理生理学具有重要的临床意义。
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