Tsompos C, Panoulis C, Toutouzas K, Triantafyllou A, Zografos G, Papalois A
Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece.
Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece.
Porto Biomed J. 2016 Nov-Dec;1(5):186-190. doi: 10.1016/j.pbj.2016.10.003. Epub 2016 Nov 9.
This experimental study examined the effect of the antioxidant drug "U-74389G", on a rat model and particularly in a hypoxia - reoxygenation protocol. The effects of that molecule were studied hematologically using blood mean platelets volume (MPV) levels.
40 rats of mean weight 231.875 g were used in the study. MPV levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D). The drug U-74389G was administered only in groups C and D.
U-74389G administration kept significantly increased the predicted MPV levels by 12.77 ± 3.07% ( = 0.0001). Reoxygenation time non-significantly decreased the predicted MPV levels by 2.55 ± 3.71% ( = 0.4103). However, U-74389G administration and reoxygenation time together kept significantly increased the predicted MPV levels by 7.09 ± 1.91% ( = 0.0005).
U-74389G administration whether it interacted or not with reoxygenation time kept significantly increased the predicted MPV levels. This finding has great clinical interest in blood clotting and coagulation pathophysiology.
本实验研究检测了抗氧化药物“U - 74389G”对大鼠模型的影响，特别是在缺氧 - 复氧实验方案中的影响。使用血液平均血小板体积（MPV）水平从血液学角度研究了该分子的作用。
本研究使用了40只平均体重为231.875克的大鼠。在复氧60分钟时（A组和C组）以及复氧120分钟时（B组和D组）测量MPV水平。仅在C组和D组中给予药物U - 74389G。
给予U - 74389G可使预测的MPV水平显著升高12.77±3.07%（P = 0.0001）。复氧时间使预测的MPV水平非显著降低2.55±3.71%（P = 0.4103）。然而，给予U - 74389G与复氧时间共同作用可使预测的MPV水平显著升高7.09±1.91%（P = 0.0005）。
无论是否与复氧时间相互作用，给予U - 74389G均可使预测的MPV水平显著升高。这一发现对血液凝固和凝血病理生理学具有重要的临床意义。
