Machmudah Siti, Winardi Sugeng, Kanda Hideki, Goto Motonobu
Department of Chemical Engineering, Sepuluh Nopember Institute of Technology, Kampus ITS Sukolilo, Surabaya 60111, Indonesia.
Department of Materials Process Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
ACS Omega. 2020 Mar 20;5(12):6705-6714. doi: 10.1021/acsomega.9b04495. eCollection 2020 Mar 31.
The production of fine particles via the supercritical carbon dioxide (SC-CO) antisolvent process was carried out. The experiments were conducted at temperatures of 40-60 °C and pressures of 8-12 MPa with a 15 mL min carbon dioxide (CO) and 0.5 mL min feed solution flow rate. As a feed solution, the curcumin and the polyvinylpyrrolidone (PVP) powder were dissolved in acetone and ethanol at concentrations of 1.0 mg mL and 2.0-4.0% in weight, respectively. Scanning electron microscopy (SEM) images described that most of the precipitated particle products have spherical morphologies with a size of less than 1 μm. The Fourier transform infrared spectroscopy (FT-IR) spectra exhibited that the curcumin structural properties did not shift after the SC-CO antisolvent process. Moreover, the PVP addition in the curcumin particle products can enhance the curcumin dissolution in distilled water significantly.
通过超临界二氧化碳（SC-CO）抗溶剂法进行了细颗粒的制备。实验在40 - 60°C的温度和8 - 12 MPa的压力下进行，二氧化碳（CO）流速为15 mL/min，进料溶液流速为0.5 mL/min。作为进料溶液，姜黄素和聚乙烯吡咯烷酮（PVP）粉末分别以1.0 mg/mL的浓度和2.0 - 4.0%（重量）溶解在丙酮和乙醇中。扫描电子显微镜（SEM）图像表明，大多数沉淀颗粒产品具有尺寸小于1μm的球形形态。傅里叶变换红外光谱（FT-IR）谱显示，姜黄素的结构性质在SC-CO抗溶剂过程后没有发生变化。此外，在姜黄素颗粒产品中添加PVP可显著提高姜黄素在蒸馏水中的溶解度。
