Gurbuz Begum Calim, Karabulut Murat Hakan, Karabulut Burak, Aydemir Merve, Inceman Hande Nur, Zemheri Itır Ebru
Department of Pathology, Health Sciences University, Umraniye Training and Research Hospital, Istanbul, Turkey.
Department of Otolaryngology, Istanbul Health Sciences University, Umraniye Training and Research Hospital, Istanbul, Turkey.
North Clin Istanb. 2019 Jul 2;7(2):187-191. doi: 10.14744/nci.2019.48991. eCollection 2020.
Epithelial-myoepithelial carcinoma is a biphasic low-grade malignant tumor, which represents approximately 1% of all salivary gland tumors. This tumor occurs mostly in the parotid gland, followed by submandibular gland and minor salivary glands. Women, mostly fifth to the eighth decade of life, are commonly affected. Histopathologically, epithelial-myoepithelial carcinoma is composed of an inner single layer of eosinophilic cuboidal ductal cells and outer single or multiple layers of clear myoepithelial cells. We present a case of a 69 years old man who had a scar on lower the lip for 10 years and voice annoyance for three months. The biopsy for lower lip was reported "infiltrative clear cell epithelioid neoplasm" and vocal cord biopsy result was "verrucous carcinoma". After cordectomy and wedge resection of the lower lip, histopathology revealed Epithelial-Myoepithelial Carcinoma for the lower lip and microinvasive verrucous carcinoma for the left vocal cord. Our case has a very uncommon location and presentation for EMC. The tumor location was minor salivary glands of the lower lip and the clinical presentation was quite different. Coexistence with microinvasive verrucous carcinoma of the vocal cord is the other unique part of our case.
上皮-肌上皮癌是一种双相性低度恶性肿瘤，约占所有涎腺肿瘤的1%。该肿瘤多发生于腮腺，其次为下颌下腺和小涎腺。女性多见，发病年龄多在50至80岁。组织病理学上，上皮-肌上皮癌由内层单层嗜酸性立方状导管细胞和外层单层或多层透明肌上皮细胞组成。我们报告一例69岁男性，下唇有瘢痕10年，声音困扰3个月。下唇活检报告为“浸润性透明细胞上皮样肿瘤”，声带活检结果为“疣状癌”。下唇行声带切除术和楔形切除术后，组织病理学显示下唇为上皮-肌上皮癌，左侧声带为微浸润疣状癌。我们的病例中上皮-肌上皮癌的部位和表现非常罕见。肿瘤位于下唇小涎腺，临床表现差异很大。与声带微浸润疣状癌并存是我们病例的另一个独特之处。
