Kadri R, Bacharouch J, Elkhoury K, Ben Messaoud G, Kahn C, Desobry S, Linder M, Tamayol A, Francius G, Mano J F, Sánchez-González L, Arab-Tehrany E
Université de Lorraine, Laboratoire Ingénierie des Biomolécules, TSA 40602, Vandoeuvre-lès-Nancy, F-54518, France.
Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA.
Mater Today Bio. 2020 Feb 27;6:100046. doi: 10.1016/j.mtbio.2020.100046. eCollection 2020 Mar.
Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.
纳米脂质体被广泛用作活性化合物的递送载体。将来自油菜籽磷脂的纳米脂质体掺入甲基丙烯酰明胶和藻酸盐的互穿聚合物网络水凝胶中。对水凝胶在3D网络表面和整个厚度上的多尺度物理化学性质进行了研究。所得复合水凝胶表现出强大的机械性能和高度多孔的表面。混合比例以及纳米脂质体的浓度会影响水凝胶的性能。纳米功能化水凝胶可诱导角质形成细胞生长。这些有利特性可能会为所开发的水凝胶在药物递送和组织工程中的许多应用开辟道路。
