Elkhoury Kamil, Morsink Margaretha, Sanchez-Gonzalez Laura, Kahn Cyril, Tamayol Ali, Arab-Tehrany Elmira
LIBio, Université de Lorraine, Nancy, F-54000, France.
Department of Applied Stem Cell Technologies, TechMed Centre, University of Twente, Enschede, 7500AE, the Netherlands.
Bioact Mater. 2021 Apr 15;6(11):3904-3923. doi: 10.1016/j.bioactmat.2021.03.040. eCollection 2021 Nov.
Natural hydrogels are one of the most promising biomaterials for tissue engineering applications, due to their biocompatibility, biodegradability, and extracellular matrix mimicking ability. To surpass the limitations of conventional fabrication techniques and to recapitulate the complex architecture of native tissue structure, natural hydrogels are being constructed using novel biofabrication strategies, such as textile techniques and three-dimensional bioprinting. These innovative techniques play an enormous role in the development of advanced scaffolds for various tissue engineering applications. The progress, advantages, and shortcomings of the emerging biofabrication techniques are highlighted in this review. Additionally, the novel applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering are discussed as well.
天然水凝胶因其生物相容性、生物可降解性和模拟细胞外基质的能力，成为组织工程应用中最具前景的生物材料之一。为了克服传统制造技术的局限性并重现天然组织结构的复杂架构，人们正在使用纺织技术和三维生物打印等新型生物制造策略来构建天然水凝胶。这些创新技术在开发用于各种组织工程应用的先进支架方面发挥着巨大作用。本文综述突出了新兴生物制造技术的进展、优点和缺点。此外，还讨论了生物制造的天然水凝胶在心脏、神经和骨组织工程中的新应用。
