SnRK1 和海藻糖 6-磷酸——两条古老的通路汇聚在一起调节植物代谢和生长。

SnRK1 and trehalose 6-phosphate - two ancient pathways converge to regulate plant metabolism and growth.

机构信息

Plant Stress Signaling, Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.

Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.

出版信息

Curr Opin Plant Biol. 2020 Jun;55:52-59. doi: 10.1016/j.pbi.2020.01.010. Epub 2020 Apr 4.

DOI:10.1016/j.pbi.2020.01.010

PMID:32259743

Abstract

SUCROSE-NON-FERMENTING1-RELATED KINASE1 (SnRK1) belongs to a family of protein kinases that originated in the earliest eukaryotes and plays a central role in energy and metabolic homeostasis. Trehalose 6-phosphate (Tre6P) is the intermediate of trehalose biosynthesis, and has even more ancient roots, being found in all three domains of life - Archaea, Bacteria and Eukarya. In plants, the function of SnRK1 has diverged from its orthologues in fungi and animals, evolving new roles in signalling of nutrient status and abiotic stress. Tre6P has also acquired a novel function in plants as a signal and homeostatic regulator of sucrose, the dominant sugar in plant metabolism. These two ancient pathways have converged in a unique way in plants, enabling them to coordinate their metabolism, growth, and development with their environment, which is essential for their autotrophic and sessile lifestyle.

摘要

蔗糖非发酵 1 相关激酶 1（SnRK1）属于蛋白激酶家族，起源于最早的真核生物，在能量和代谢稳态中发挥核心作用。海藻糖 6-磷酸（Tre6P）是海藻糖合成的中间产物，具有更古老的起源，存在于生命的三个领域——古菌、细菌和真核生物。在植物中，SnRK1 的功能已经与其在真菌和动物中的同源物分化，在营养状况和非生物胁迫信号转导中进化出了新的作用。Tre6P 在植物中也获得了作为蔗糖信号和内稳态调节剂的新功能，蔗糖是植物代谢中的主要糖。这两条古老的途径以独特的方式在植物中汇聚，使它们能够协调其代谢、生长和发育与其环境，这对它们自养和固着的生活方式至关重要。