与电子烟或雾化产品使用相关的肺损伤（EVALI）中涉及的化学成分。
Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI).
作者信息
Muthumalage Thivanka, Friedman Michelle R, McGraw Matthew D, Ginsberg Garry, Friedman Alan E, Rahman Irfan
机构信息
Department of Environmental Medicine, University of Rochester Medical Center Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Department of Chemistry & Biochemistry, The College of Brockport, State University of New York, Brockport, NY 14420, USA.
出版信息
Toxics. 2020 Apr 3;8(2):25. doi: 10.3390/toxics8020025.
Abstract
The Centers for Disease Control declared e-cigarette, or vaping, product use-associated lung injury (EVALI) a national outbreak due to the high incidence of emergency department admissions and deaths. We have identified chemical constituents in e-cig counterfeit cartridges and compared these to medical-grade and CBD containing cartridges. Apart from vitamin E acetate (VEA) and tetrahydrocannabinol (THC), other potential toxicants were identified including solvent-derived hydrocarbons, silicon conjugated compounds, various terpenes, pesticides/plasticizers/polycaprolactones, and metals. This study provides additional insights into the chemicals associated with EVALI cartridges and thus may contribute to the underlying disease mechanism of acute lung injury.
摘要
美国疾病控制中心宣布，由于急诊室入院率和死亡率居高不下，电子烟或雾化产品使用相关肺损伤（EVALI）已成为全国性疫情。我们已确定了电子烟假冒烟弹中的化学成分，并将其与医用级和含CBD的烟弹进行了比较。除了醋酸维生素E（VEA）和四氢大麻酚（THC）外，还鉴定出了其他潜在毒物，包括溶剂衍生的碳氢化合物、硅共轭化合物、各种萜类化合物、农药/增塑剂/聚己内酯以及金属。这项研究为与EVALI烟弹相关的化学物质提供了更多见解，因此可能有助于了解急性肺损伤的潜在发病机制。
相似文献
1
Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI).与电子烟或雾化产品使用相关的肺损伤（EVALI）中涉及的化学成分。
Toxics. 2020 Apr 3;8(2):25. doi: 10.3390/toxics8020025.
2
E-cigarette vaping associated acute lung injury (EVALI): state of science and future research needs.电子烟相关的急性肺损伤（EVALI）：科学现状与未来研究需求。
Crit Rev Toxicol. 2022 Mar;52(3):188-220. doi: 10.1080/10408444.2022.2082918. Epub 2022 Jul 13.
3
Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury.肺部毒性与电子烟或雾化产品使用相关肺损伤的病理生理学
Front Pharmacol. 2020 Jan 14;10:1619. doi: 10.3389/fphar.2019.01619. eCollection 2019.
4
Characteristics of E-cigarette, or Vaping, Products Used by Patients with Associated Lung Injury and Products Seized by Law Enforcement - Minnesota, 2018 and 2019.电子烟或蒸气烟产品的特点与相关肺损伤患者使用的产品和执法部门查获的产品——明尼苏达州，2018 年和 2019 年。
MMWR Morb Mortal Wkly Rep. 2019 Nov 29;68(47):1096-1100. doi: 10.15585/mmwr.mm6847e1.
5
E-cigarette, or Vaping, Product Use-Associated Lung Injury Among Clusters of Patients Reporting Shared Product Use - Wisconsin, 2019.电子烟或蒸气产品使用相关肺损伤在报告共同使用产品的患者群中出现-威斯康星州，2019 年。
MMWR Morb Mortal Wkly Rep. 2020 Mar 6;69(9):236-240. doi: 10.15585/mmwr.mm6909a4.
6
Investigation of Vaping Fluids Recovered From New York State E-Cigarette or Vaping Product Use-Associated Lung Injury Patients.对从纽约州电子烟或雾化产品使用相关肺损伤患者身上回收的雾化液的调查。
Front Chem. 2021 Oct 27;9:748935. doi: 10.3389/fchem.2021.748935. eCollection 2021.
7
Risk Factors for E-Cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) Among Adults Who Use E-Cigarette, or Vaping, Products - Illinois, July-October 2019.与使用电子烟相关的肺损伤（EVALI）的成人中电子烟或蒸气产品使用相关的风险因素-伊利诺伊州，2019 年 7 月至 10 月。
MMWR Morb Mortal Wkly Rep. 2019 Nov 15;68(45):1034-1039. doi: 10.15585/mmwr.mm6845e1.
8
Update: Characteristics of a Nationwide Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury - United States, August 2019-January 2020.更新：2019 年 8 月至 2020 年 1 月与电子烟或蒸气产品使用相关的肺损伤的全国性暴发的特征 - 美国。
MMWR Morb Mortal Wkly Rep. 2020 Jan 24;69(3):90-94. doi: 10.15585/mmwr.mm6903e2.
9
Review of Health Consequences of Electronic Cigarettes and the Outbreak of Electronic Cigarette, or Vaping, Product Use-Associated Lung Injury.电子烟健康危害及电子烟产品使用相关肺损伤爆发的综述。
J Med Toxicol. 2020 Jul;16(3):295-310. doi: 10.1007/s13181-020-00772-w. Epub 2020 Apr 16.
10
Update: Characteristics of Patients in a National Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injuries - United States, October 2019.更新：2019 年 10 月美国与电子烟或蒸气相关的肺损伤爆发中患者的特征。
MMWR Morb Mortal Wkly Rep. 2019 Nov 1;68(43):985-989. doi: 10.15585/mmwr.mm6843e1.
引用本文的文献
1
Heavy Metals in Cannabis Vapes and Their Health Implications-A Scoping Review.大麻电子烟中的重金属及其对健康的影响——一项范围综述
ScientificWorldJournal. 2025 Aug 19;2025:9529544. doi: 10.1155/tswj/9529544. eCollection 2025.
2
Mobilizing for Health: A Case Study of Kazakhstan's Vaping Ban Advocacy Campaign.为健康动员：哈萨克斯坦电子烟禁令宣传活动的案例研究。
Int J Environ Res Public Health. 2025 Jul 13;22(7):1102. doi: 10.3390/ijerph22071102.
3
Severe E-Cigarette-Induced Esophagitis in a Patient With Eosinophilic Esophagitis: A Case Report.嗜酸性食管炎患者中严重的电子烟诱发食管炎：一例报告
Cureus. 2025 May 6;17(5):e83563. doi: 10.7759/cureus.83563. eCollection 2025 May.
4
The effects of flavored vaped e-liquids on cultured human macrophages derived from the central and peripheral nervous systems.调味电子烟液对源自中枢和外周神经系统的培养人巨噬细胞的影响。
Toxicol In Vitro. 2025 Apr;104:106013. doi: 10.1016/j.tiv.2025.106013. Epub 2025 Jan 31.
5
A multi-market comparison of composition, formulation, and label content of CBD e-liquids.大麻二酚电子烟液的成分、配方和标签内容的多市场比较。
iScience. 2024 Oct 15;27(11):111154. doi: 10.1016/j.isci.2024.111154. eCollection 2024 Nov 15.
6
Long-term trends in adolescent alcohol, tobacco and cannabis use and emerging substance use issues in Aotearoa New Zealand.新西兰青少年酒精、烟草和大麻使用的长期趋势以及新出现的物质使用问题。
J R Soc N Z. 2022 Apr 20;52(4):450-471. doi: 10.1080/03036758.2022.2060266. eCollection 2022.
7
GC/HRMS Analysis of E-Liquids Complements In Vivo Modeling Methods and can Help to Predict Toxicity.电子液体的气相色谱/高分辨率质谱分析补充了体内建模方法，有助于预测毒性。
ACS Omega. 2024 Jun 5;9(24):26641-26650. doi: 10.1021/acsomega.4c03416. eCollection 2024 Jun 18.
8
Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring.孕期尼古丁或大麻雾化暴露与后代免疫反应改变
J Environ Expo Assess. 2024;3(1). doi: 10.20517/jeea.2024.03. Epub 2024 Apr 15.
9
Vaping, Environmental Toxicants Exposure, and Lung Cancer Risk.电子烟使用、环境毒物暴露与肺癌风险
Cancers (Basel). 2023 Sep 12;15(18):4525. doi: 10.3390/cancers15184525.
10
Multi-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure.多组学评估显示电子烟暴露引起肺和全身免疫失调。
Respir Res. 2023 May 25;24(1):138. doi: 10.1186/s12931-023-02441-2.
本文引用的文献
1
Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury.肺部毒性与电子烟或雾化产品使用相关肺损伤的病理生理学
Front Pharmacol. 2020 Jan 14;10:1619. doi: 10.3389/fphar.2019.01619. eCollection 2019.
2
Are Electronic Cigarette Users at Risk for Lipid-mediated Lung Injury?电子烟使用者会面临脂质介导的肺损伤风险吗？
Am J Respir Crit Care Med. 2020 Apr 15;201(8):1012-1013. doi: 10.1164/rccm.201910-2082LE.
3
Vaping-related Lung Injury in an Adolescent.一名青少年的电子烟相关肺损伤
Am J Respir Crit Care Med. 2020 Feb 15;201(4):481-482. doi: 10.1164/rccm.201909-1786IM.
4
Syndromic Surveillance for E-Cigarette, or Vaping, Product Use-Associated Lung Injury.电子烟或雾化产品使用相关肺损伤的症状监测
N Engl J Med. 2020 Feb 20;382(8):766-772. doi: 10.1056/NEJMsr1915313. Epub 2019 Dec 20.
5
Vitamin E acetate is not present in licit e-cigarette products available on the UK market.维生素 E 醋酸酯并不存在于英国市场上合法的电子烟产品中。
Addiction. 2020 Apr;115(4):782-783. doi: 10.1111/add.14920. Epub 2020 Jan 16.
6
Vaping-associated lung illnesses highlight risks to all users of electronic cigarettes.与吸电子烟相关的肺部疾病凸显了电子烟所有使用者面临的风险。
CMAJ. 2019 Dec 2;191(48):E1319-E1320. doi: 10.1503/cmaj.191503. Epub 2019 Nov 20.
7
Characteristics of Hospitalized and Nonhospitalized Patients in a Nationwide Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury - United States, November 2019.在全国范围内爆发的电子烟或蒸气产品使用相关肺损伤的住院和非住院患者的特征 - 美国，2019 年 11 月。
MMWR Morb Mortal Wkly Rep. 2019 Nov 22;68(46):1076-1080. doi: 10.15585/mmwr.mm6846e1.
8
Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury - 10 States, August-October 2019.评估电子烟或蒸气产品使用相关肺损伤爆发期间患者的支气管肺泡灌洗液 - 10 个州，2019 年 8 月至 10 月。
MMWR Morb Mortal Wkly Rep. 2019 Nov 15;68(45):1040-1041. doi: 10.15585/mmwr.mm6845e2.
9
E-cigarette, or vaping, product use associated lung injury (EVALI): case series and diagnostic approach.电子烟或蒸气烟产品使用相关肺损伤（EVALI）：病例系列和诊断方法。
Lancet Respir Med. 2019 Dec;7(12):1017-1026. doi: 10.1016/S2213-2600(19)30415-1. Epub 2019 Nov 8.
10
Vaping-associated Acute Lung Injury: A Case Series.电子烟相关急性肺损伤：病例系列
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1430-1431. doi: 10.1164/rccm.201909-1809LE.
Zotero 插件