Santi Daniele, Crépieux Pascale, Reiter Eric, Spaggiari Giorgia, Brigante Giulia, Casarini Livio, Rochira Vincenzo, Simoni Manuela
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, 41126 Modena, Italy.
J Clin Med. 2020 Apr 3;9(4):1014. doi: 10.3390/jcm9041014.
Human reproduction is regulated by the combined action of the follicle-stimulating hormone (FSH) and the luteinizing hormone (LH) on the gonads. Although FSH is largely used in female reproduction, in particular in women attending assisted reproductive techniques to stimulate multi-follicular growth, its efficacy in men with idiopathic infertility is not clearly demonstrated. Indeed, whether FSH administration improves fertility in patients with hypogonadotropic hypogonadism, the therapeutic benefit in men presenting alterations in sperm production despite normal FSH serum levels is still unclear. In the present review, we evaluate the potential pharmacological benefits of FSH administration in clinical practice.
This is a narrative review, describing the FSH physiological role in spermatogenesis and its potential therapeutic action in men.
The FSH role on male fertility is reviewed starting from the physiological control of spermatogenesis, throughout its mechanism of action in Sertoli cells, the genetic regulation of its action on spermatogenesis, until the therapeutic options available to improve sperm production.
FSH administration in infertile men has potential benefits, although its action should be considered by evaluating its synergic action with testosterone, and well-controlled, powerful trials are required. Prospective studies and new compounds could be developed in the near future.
人类生殖受促卵泡生成素（FSH）和促黄体生成素（LH）对性腺的联合作用调节。尽管FSH在女性生殖中广泛应用，尤其是在接受辅助生殖技术以刺激多卵泡生长的女性中，但它在特发性不育男性中的疗效尚未得到明确证实。事实上，给予FSH是否能提高低促性腺激素性性腺功能减退患者的生育能力，对于血清FSH水平正常但精子生成存在改变的男性的治疗益处仍不明确。在本综述中，我们评估了临床实践中给予FSH的潜在药理学益处。
这是一篇叙述性综述，描述了FSH在精子发生中的生理作用及其在男性中的潜在治疗作用。
从精子发生的生理控制开始，回顾FSH对男性生育能力的作用，贯穿其在支持细胞中的作用机制、其对精子发生作用的基因调控，直至可用于改善精子生成的治疗选择。
给予不育男性FSH有潜在益处，尽管其作用应通过评估其与睾酮的协同作用来考虑，并且需要精心设计、有力的试验。未来可能会开展前瞻性研究并开发新的化合物。
