Department of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea.
Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Korea.
Int J Mol Sci. 2020 Apr 3;21(7):2502. doi: 10.3390/ijms21072502.
Present-day lifestyles associated with high calorie-fat intake and accumulation, as well as energy imbalance, have led to the development of obesity and its comorbidities, which have emerged as some of the major health issues globally. To combat the disease, many studies have reported the anti-obesity effects of natural compounds in foods, with some advantages over chemical treatments. Carotenoids, such as xanthophyll derived from seaweeds, have attracted the attention of researchers due to their notable biological activities, which are associated mainly with their antioxidant properties. Their involvement in oxidative stress modulation, the regulation of major transcription factors and enzymes, and their antagonistic effects on various obesity parameters have been examined in both in vitro and in vivo studies. The present review is a collation of published research over the last decade on the antioxidant properties of seaweed xanthophyll carotenoids, with a focus on fucoxanthin and astaxanthin and their mechanisms of action in obesity prevention and treatment.
如今的生活方式与高热量高脂肪的摄入以及能量失衡有关，这些因素导致了肥胖及其合并症的发生，这些问题已成为全球主要的健康问题之一。为了对抗这种疾病，许多研究已经报道了食物中天然化合物的抗肥胖作用，它们在某些方面优于化学治疗。类胡萝卜素，如来自海藻的叶黄素，由于其显著的生物活性而引起了研究人员的关注，这些生物活性主要与它们的抗氧化特性有关。在体外和体内研究中，已经研究了它们在氧化应激调节、主要转录因子和酶的调节以及对各种肥胖参数的拮抗作用中的作用。本综述汇集了过去十年中关于海藻叶黄素类胡萝卜素的抗氧化特性的已发表研究，重点介绍了岩藻黄质和虾青素及其在预防和治疗肥胖症中的作用机制。
