Pereira Antia G, Echave Javier, Jorge Ana O S, Nogueira-Marques Rafael, Nur Yuksek Ezgi, Barciela Paula, Perez-Vazquez Ana, Chamorro Franklin, P P Oliveira Maria B, Carpena Maria, Prieto Miguel A
Universidade de Vigo, Nutrition and Food Group (NuFoG), Department of Analytical Chemistry and Food Science, Instituto de Agroecoloxía e Alimentación (IAA)-CITEXVI, 36310 Vigo, Spain.
Investigaciones Agroalimentarias Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
Foods. 2025 May 14;14(10):1749. doi: 10.3390/foods14101749.
Oxidative stress and its relation to the onset of several chronic diseases have been increasingly highlighted in recent years. In parallel, there has been an increasing interest in the antioxidant properties of phytochemicals. Phytochemicals are products of plant secondary metabolism, including structural polysaccharides, unsaturated fatty acids, pigments (chlorophylls, carotenoids, and anthocyanins), or phenolic compounds. Phytochemicals can be obtained from lower and higher plants, their fruits, and even from macro- or microalgae. Their diverse structural features are linked to different beneficial effects through various molecular mechanisms, contributing to disease prevention. Beyond antioxidant activity, many phytochemicals also display anti-inflammatory, antidiabetic, anti-obesity, and neuroprotective effects, which can be intertwined. Beyond these, other natural antioxidants can also be obtained from animal, fungal, and bacterial sources. Thus, a wide range of antioxidants have the potential to be used as nutraceuticals with chemopreventive effects on the onset of various diseases related to antioxidant stress. Given their enormous structural and sourcing diversity, the present work provides an updated insight into the therapeutic and preventive potential of plant-derived antioxidants and nutraceuticals.
近年来，氧化应激及其与几种慢性疾病发病的关系越来越受到关注。与此同时，人们对植物化学物质的抗氧化特性越来越感兴趣。植物化学物质是植物次生代谢的产物，包括结构多糖、不饱和脂肪酸、色素（叶绿素、类胡萝卜素和花青素）或酚类化合物。植物化学物质可以从低等和高等植物、它们的果实，甚至从大型或微型藻类中获得。它们多样的结构特征通过各种分子机制与不同的有益作用相关联，有助于疾病预防。除了抗氧化活性外，许多植物化学物质还具有抗炎、抗糖尿病、抗肥胖和神经保护作用，这些作用可能相互交织。除此之外，其他天然抗氧化剂也可以从动物、真菌和细菌来源获得。因此，广泛的抗氧化剂有潜力用作营养保健品，对与抗氧化应激相关的各种疾病的发病具有化学预防作用。鉴于其巨大的结构和来源多样性，本研究对植物源抗氧化剂和营养保健品的治疗和预防潜力提供了最新的见解。
