Chen Na, Shi Xuetao, Witte Ralf, Nakayama Koji S, Ohmura Kazuyo, Wu Hongkai, Takeuchi Akira, Hahn Horst, Esashi Masayoshi, Gleiter Herbert, Inoue Akihisa, Louzguine Dmitri V
WPI Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai 980-8577, Japan.
J Mater Chem B. 2013 May 28;1(20):2568-2574. doi: 10.1039/c3tb20153h. Epub 2013 Apr 12.
Owing to recent progress in nanotechnology, the ability to tune the surface properties of metals has opened an avenue for creating a new generation of biomaterials. Here we demonstrate the successful development of a novel Ti-based nanoglass composite with submicron-nanometer-sized hierarchical glassy structures. A first exploratory study was performed on the application of the unique nanostructure to modulate osteoblast behaviors. Our results show that this Ti-based nanoglass composite, relative to conventional metallic glasses, exhibits significantly improved biocompatibility. In fact, a 10 times enhancement in cell proliferation has been achieved. To a great extent, this superior bioactivity (such as enhanced cell proliferation and osteogenic phenotype) is promoted by its unique hierarchical structures combining nanoglobules and submicron button-like clusters from collective packing of these nanoglobules. This nanoglass composite could be widely applicable for surface modifications by means of coating on various materials including BMGs, crystalline metals or ceramics. Therefore, our successful experimental testing of this nanostructured metallic glass may open the way to new applications in novel biomaterial design for the purpose of bone replacement.
由于纳米技术的最新进展，调节金属表面性质的能力为新一代生物材料的创造开辟了一条途径。在此，我们展示了一种具有亚微米-纳米级分级玻璃结构的新型钛基纳米玻璃复合材料的成功研发。针对这种独特纳米结构在调节成骨细胞行为方面的应用进行了首次探索性研究。我们的结果表明，相对于传统金属玻璃，这种钛基纳米玻璃复合材料表现出显著改善的生物相容性。事实上，细胞增殖提高了10倍。在很大程度上，这种卓越的生物活性（如增强的细胞增殖和成骨表型）是由其独特的分级结构所促进的，该结构结合了纳米球以及由这些纳米球的集体堆积形成的亚微米纽扣状簇。这种纳米玻璃复合材料可通过涂覆在包括生物医学玻璃、晶体金属或陶瓷在内的各种材料上广泛应用于表面改性。因此，我们对这种纳米结构金属玻璃的成功实验测试可能为用于骨替代的新型生物材料设计的新应用开辟道路。
