Xu He, Li Haiyan, Chang Jiang
School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 HuaShan Road, Shanghai 200030, People's Republic of China.
J Mater Chem B. 2013 Sep 7;1(33):4182-4188. doi: 10.1039/c3tb20404a. Epub 2013 Jul 5.
In this work, we investigated the relationship between the micro/nanostructures of electrospun nanofibrous layers on polymer materials and the corresponding surface hydrophobicity, and further evaluated the possibility of controlling drug release from a polymer matrix by adjusting the micro/nanopatterned electrospun structures on the surface. Polyvinyl butyral (PVB) polymer films with different PVB electrospun nanofibrous structures and patterns on the surface were prepared by controlling the density and patterns of the PVB electrospun nanofibers. The effects of the electrospun nanoscaled fibrous and micro-patterned structures on the hydrophobicity of the PVB film surface were investigated. The results showed that the surface hydrophobicity of PVB films could be controlled over a large range (water contact angle from 80° to 153.2°) by changing the density, distribution and the arrangement of the deposited electrospun nanofibers on the surface. Furthermore, the in vitro drug release characteristics of PVB polymer films with hydrophobic surface modifications were studied. The results indicated that the hydrophobic surface created by nanofibrous structures on the PVB film could reduce the drug release rate from the PVB polymer film, and the drug release profile could be further tuned by changing the pattern arrangement of the nanofibers on the surface of the materials. In summary, this study demonstrated a possible way to control the drug release from a polymer matrix by modifying the surface with different hydrophobic micro/nanostructures.
在本研究中，我们探究了聚合物材料上静电纺纳米纤维层的微/纳米结构与相应表面疏水性之间的关系，并进一步评估了通过调整表面微/纳米图案化的静电纺结构来控制聚合物基质中药物释放的可能性。通过控制聚乙烯醇缩丁醛（PVB）静电纺纳米纤维的密度和图案，制备了表面具有不同PVB静电纺纳米纤维结构和图案的聚合物薄膜。研究了静电纺纳米级纤维和微图案结构对PVB薄膜表面疏水性的影响。结果表明，通过改变表面沉积的静电纺纳米纤维的密度、分布和排列，可以在很大范围内控制PVB薄膜的表面疏水性（水接触角从80°到153.2°）。此外，还研究了具有疏水表面改性的PVB聚合物薄膜的体外药物释放特性。结果表明，PVB薄膜上纳米纤维结构形成的疏水表面可降低PVB聚合物薄膜的药物释放速率，并且通过改变材料表面纳米纤维的图案排列可以进一步调节药物释放曲线。总之，本研究展示了一种通过用不同的疏水微/纳米结构修饰表面来控制聚合物基质中药物释放的可能方法。
