School of Science, China Pharmaceutical University, Nanjing, China.
Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing, China.
Tissue Eng Part A. 2021 Jun;27(11-12):724-732. doi: 10.1089/ten.TEA.2020.0258. Epub 2020 Dec 8.
Electrospun nanofibers is a promising and versatile avenue for building controlled drug release system because of the facile fabrication and the broad range of polymer materials. This research systematically studied the morphological effect of thermosensitive electrospun nanofibers, including porous and coaxial structures, on controllable drug release. Three types of drugs, nicotinamide, paracetamol, and ibuprofen, with different hydrophilicity were applied in this study. The data of drug release were all fitted to the first-order kinetic model regardless of the drug properties, and the release rates paralleled with their hydrophilicity. Sol-gel phase transition of the thermosensitive poly(-isopropylacrylamide) (PNIPAAm) hydrogel led to slower drug release at 37°C compared with those at 25°C. Regarding morphology, coaxial nanofibers could provide higher loading efficiency and slower drug release rather than porous nanofibers. Our research highlighted the overall effects of compound property, temperature, and the morphological structures of thermosensitive electrospun nanofibers on the controlled drug release. Our results concluded that hydrophobic drug encapsulated in the core-shell PNIPAAm nanofibers could perform excellent sustained release and also controllable release under temperature stumuli. Impact statement The behaviors for the controlled release of drugs loaded in the thermosensitive electrospun nanofibers could be affected by various factors including the properties of loaded drug, morphologies of nanofibrous, and lower critical solution temperatures of thermosensitive hydrogels. However, few systematical investigations have been performed in this area. In this article, we designed and fabricated porous and coaxial thermosensitive poly(-isopropylacrylamide) electrospun nanofibers with different drug loading to study the comprehensive effect. This study suggested when adopting thermosensitive electrospun hydrogel nanofibers as the controllable drug release carrier, the hydrophilicity of loaded compounds and the morphologies of nanofibers are necessary to be optimized.
静电纺丝纳米纤维是构建控制药物释放系统的一种很有前途且用途广泛的方法，因为其易于制造和广泛的聚合物材料。本研究系统地研究了热响应性静电纺丝纳米纤维的形态效应，包括多孔和同轴结构，对可控药物释放的影响。本研究应用了三种不同亲水性的药物，烟酰胺、扑热息痛和布洛芬。无论药物性质如何，药物释放数据均符合一级动力学模型，释放速率与亲水性平行。温敏性聚（异丙基丙烯酰胺）（PNIPAAm）水凝胶的溶胶-凝胶相转变导致在 37°C 时药物释放速度比在 25°C 时慢。就形态而言，同轴纳米纤维可以提供更高的载药效率和更慢的药物释放，而不是多孔纳米纤维。我们的研究强调了复合性质、温度和温敏性静电纺丝纳米纤维形态结构对控制药物释放的综合影响。研究结果表明，疏水性药物包封在核壳结构的 PNIPAAm 纳米纤维中，可以实现优异的持续释放，并且在温度刺激下也可以进行可控释放。
