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用于胶质瘤治疗的靶向肿瘤相关纤连蛋白的肽缀合脂质体。

Aptide-conjugated liposome targeting tumor-associated fibronectin for glioma therapy.

作者信息

Saw Phei Er, Kim Sunghyun, Lee In-Hyun, Park Jinho, Yu Mikyung, Lee Jinju, Kim Jae-Il, Jon Sangyong

机构信息

KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon 305-701, Republic of Korea.

出版信息

J Mater Chem B. 2013 Oct 7;1(37):4723-4726. doi: 10.1039/c3tb20815j. Epub 2013 Aug 20.

DOI:10.1039/c3tb20815j
PMID:32261155
Abstract

Aptides, developed by our laboratory, are a novel class of high-affinity peptides. Here, we describe the conjugation of an aptide targeting extra-domain B (EDB) of tumor-associated fibronectin to drug-containing liposomes and explore the potential of these aptide-conjugated liposomes as a robust and efficient targeted drug-delivery system for glioma therapy.

摘要

我们实验室研发的亲和肽是一类新型的高亲和力肽。在此，我们描述了一种靶向肿瘤相关纤连蛋白额外结构域B（EDB）的亲和肽与载药脂质体的缀合，并探讨了这些亲和肽缀合脂质体作为一种强大而有效的靶向给药系统用于胶质瘤治疗的潜力。

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