通过迈克尔加成反应与钆（III）螯合物功能化的水溶性金纳米颗粒（AuNP）用作磁共振成像（MRI）造影剂。
Water-soluble gold nanoparticles (AuNP) functionalized with a gadolinium(iii) chelate via Michael addition for use as a MRI contrast agent.
作者信息
Milne Mark, Gobbo Pierangelo, McVicar Nevin, Bartha Robert, Workentin Mark S, Hudson Robert H E
机构信息
Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
出版信息
J Mater Chem B. 2013 Nov 7;1(41):5628-5635. doi: 10.1039/c3tb20699h. Epub 2013 Sep 17.
A contrast agent suitable for magnetic resonance imaging based on small, water soluble gold nanoparticles (AuNP) conjugated to over 50 Gd chelators has been prepared by using an interfacial Michael addition in aqueous media. The resultant chelator-AuNP conjugates have been successfully characterised by H NMR spectroscopy, IR spectroscopy, ICP-OES, ζ-potential analysis, TEM and MRI. T-weighted in vivo images of mouse kidney were obtained using the agent at 9.4 T. A preliminary in vivo experiment produced no ill effects and the clearance profile of the agent suggests it is suitable for animal testing at clinically relevant concentrations.
通过在水介质中进行界面迈克尔加成反应，制备了一种基于与50多个钆螯合剂共轭的小尺寸水溶性金纳米颗粒（AuNP）的适用于磁共振成像的造影剂。所得的螯合剂 - AuNP共轭物已通过1H NMR光谱、红外光谱、电感耦合等离子体发射光谱法（ICP - OES）、ζ电位分析、透射电子显微镜（TEM）和磁共振成像（MRI）成功表征。在9.4 T下使用该造影剂获得了小鼠肾脏的T加权体内图像。初步的体内实验未产生不良影响，并且该造影剂的清除曲线表明它适用于临床相关浓度下的动物试验。
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