硝酮修饰的金纳米粒子：合成、表征及其通过I-SPANC作为F标记正电子发射断层扫描探针的潜力。

Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as F-Labeled Positron Emission Tomography Probes via I-SPANC.

作者信息

Ghiassian Sara, Yu Lihai, Gobbo Pierangelo, Nazemi Ali, Romagnoli Tommaso, Luo Wilson, Luyt Leonard G, Workentin Mark S

机构信息

Department of Chemistry and the Center for Materials and Biomaterials Research and Department of Oncology, The University of Western Ontario, London N6A 5B7, Ontario, Canada.

London Regional Cancer Program, 800 Commissioners Rd. E., London N6A 5W9, Ontario, Canada.

出版信息

ACS Omega. 2019 Nov 8;4(21):19106-19115. doi: 10.1021/acsomega.9b02322. eCollection 2019 Nov 19.

A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne-nitrone cycloaddition reactions has been synthesized. These nitrone-AuNPs were characterized in detail using H nuclear magnetic resonance spectroscopy, transmission electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy, and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the nitrone-AuNP template allowed us to create a novel methodology for the synthesis of AuNP-based radiolabeled probes.