Pretze Marc, von Kiedrowski Valeska, Runge Roswitha, Freudenberg Robert, Hübner René, Davarci Güllü, Schirrmacher Ralf, Wängler Carmen, Wängler Björn
Department of Nuclear Medicine, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.
Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, 68167 Mannheim, Germany.
Nanomaterials (Basel). 2021 Jan 8;11(1):138. doi: 10.3390/nano11010138.
This paper reports on the development of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via optical imaging (OI) before therapy is performed, being initiated via an external X-ray irradiation source. The AuNPs were decorated with a near-infrared dye, and RGD peptides as the tumor targeting vector for αβ-integrin, which is overexpressed in tissue with high tumor angiogenesis. The AuNPs were evaluated in an optical imaging setting in vitro and in vivo exhibiting favorable diagnostic properties with regards to tumor cell accumulation, biodistribution, and clearance. Furthermore, the therapeutic properties of the AuNPs were evaluated in vitro on pUC19 DNA and on A431 cells concerning acute and long-term toxicity, indicating that these AuNPs could be useful as radiosensitizers in therapeutic concepts in the future.
本文报道了肿瘤特异性金纳米颗粒（AuNP）的研发情况，其作为一种诊疗工具，旨在通过光学成像（OI）实现靶向聚集并在治疗前检测肿瘤血管生成，该过程由外部X射线辐射源启动。AuNP用近红外染料和RGD肽进行修饰，RGD肽作为αβ整合素的肿瘤靶向载体，αβ整合素在肿瘤血管生成高的组织中过表达。在体外和体内光学成像环境中对AuNP进行了评估，结果显示其在肿瘤细胞聚集、生物分布和清除方面具有良好的诊断特性。此外，在体外对AuNP针对pUC19 DNA和A431细胞的急性和长期毒性进行了治疗特性评估，表明这些AuNP未来在治疗理念中可作为放射增敏剂发挥作用。
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