Wu Meiying, Chen Yu, Zhang Lingxia, Li Xiaoyu, Cai Xiaojun, Du Yanyan, Zhang Linlin, Shi Jianlin
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, PR China.
J Mater Chem B. 2015 Feb 7;3(5):766-775. doi: 10.1039/c4tb01581a. Epub 2014 Dec 3.
A salt-assisted acid etching (SAAE) strategy has been developed to construct rattle/hollow mesoporous silica/organosilica nanovehicles (R/HMSVs or R/HMOVs), which settles the drawbacks of traditional silica etching approaches, such as undesirable by-products, by alkaline etching and strong corrosion of the HF etching process. The hollow structure and phenylene-bridged framework of HMOVs were found to be responsible for the high cargo-loading capacity and pH-responsive drug releasing behavior, respectively, based on the special cargo-framework interaction. Especially, the molecularly organic-inorganic hybrid HMOVs have been, for the first time, successfully engineered to concurrently deliver anticancer drugs and P-gp-associated shRNA molecules for enhancing the intracellular drug concentrations and reversing the multidrug resistance (MDR) of cancer cells. On the basis of this special SAAE strategy, a wide range of mesoporous silica-based hollow nanostructures are anticipated to be synthesized to satisfy the strict requirements in various nano-catalytic and biomedical applications.
一种盐辅助酸蚀刻（SAAE）策略已被开发用于构建响尾蛇状/中空介孔二氧化硅/有机硅纳米载体（R/HMSV或R/HMOV），该策略解决了传统二氧化硅蚀刻方法的缺点，如碱性蚀刻产生不良副产物以及氢氟酸蚀刻过程的强腐蚀性。基于特殊的载药-骨架相互作用，发现HMOV的中空结构和亚苯基桥连骨架分别导致了高载药量和pH响应性药物释放行为。特别是，分子有机-无机杂化的HMOV首次被成功设计用于同时递送抗癌药物和P-糖蛋白相关的短发夹RNA分子，以提高细胞内药物浓度并逆转癌细胞的多药耐药性（MDR）。基于这种特殊的SAAE策略，预计可合成多种介孔二氧化硅基中空纳米结构，以满足各种纳米催化和生物医学应用中的严格要求。
