Zhao Decai, Yang Nailiang, Xu Lekai, Du Jiang, Yang Yang, Wang Dan
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 China.
University of Chinese Academy of Sciences, Beijing, 100049 China.
Nano Res. 2022;15(2):739-757. doi: 10.1007/s12274-021-3595-5. Epub 2021 Jul 8.
Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surface-to-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.
由于其独特的结构，如高比表面积、低密度、大空腔和分级孔隙，中空结构在药物递送方面已展现出巨大潜力。在本综述中，我们全面概述了应用于靶向识别、智能响应和药物释放的中空结构材料，并探讨了这三个过程中可能的化学因素和反应。中空纳米结构的优势总结如下：中空腔有助于实现高负载量；定制结构有助于可控药物释放；可变化合物适应灵活应用；表面修饰便于智能响应释放。特别是，由于多壳层可诱导多种物理屏障和化学相互作用，中空多壳层结构被认为是一种具有独特负载和释放特性的有前景的材料。最后，我们以对中空结构作为药物载体的未来研发的一些展望来结束本综述。
